TANK binds polyubiquitinated TRAF3/6

Stable Identifier
R-GGA-1227867
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
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TANK (TRAF family member-associated NF-kB activator) is a TRAF-binding protein [Rothe M et al 1996; Pomeranz JL and Baltimore D 1999; Li C et al 2002; Guo B and Cheng G 2007; Konno H 2009] that has been implicated in RLR, TNFR and IL-1R/TLR signaling pathways in mammals. TANK was also shown to interact with TBK1, IKK epsilon, IPS-1, TRIF and IRF3 [Pomeranz JL and Baltimore D 1999,Guo B and Cheng G 2007]. Upon viral stimulation TANK is believed to induce type I IFN production by linking kinases TBK1/IKK epsilon with upstream mediators, while its role in NF-kB signaling remains elusive. TANK was reported to act as either positive[GuoB and Cheng G 2007, Konno H et al 2009, Pomerantz JL and Baltimore D 1999] or negative regulator of TRAF-mediated NF-kB induction [Kawagoe T et al 2009].

Predicted chicken TANK protein shows 51% amino acid sequence identity to its human counterpart.

Literature References
PubMed ID Title Journal Year
17327220 Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

Guo, B, Cheng, G

J Biol Chem 2007
17332413 Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

Tenoever, BR, Ng, SL, Chua, MA, McWhirter, SM, Garcia-Sastre, A, Maniatis, T

Science 2007
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