TANK binds polyubiquitinated TRAF3/6

Stable Identifier
R-GGA-1227867
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
mitochondrial outer membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TANK binds polyubiquitinated TRAF3/6
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TANK (TRAF family member-associated NF-kB activator) is a TRAF-binding protein [Rothe M et al 1996; Pomeranz JL and Baltimore D 1999; Li C et al 2002; Guo B and Cheng G 2007; Konno H 2009] that has been implicated in RLR, TNFR and IL-1R/TLR signaling pathways in mammals. TANK was also shown to interact with TBK1, IKK epsilon, IPS-1, TRIF and IRF3 [Pomeranz JL and Baltimore D 1999,Guo B and Cheng G 2007]. Upon viral stimulation TANK is believed to induce type I IFN production by linking kinases TBK1/IKK epsilon with upstream mediators, while its role in NF-kB signaling remains elusive. TANK was reported to act as either positive[GuoB and Cheng G 2007, Konno H et al 2009, Pomerantz JL and Baltimore D 1999] or negative regulator of TRAF-mediated NF-kB induction [Kawagoe T et al 2009].

Predicted chicken TANK protein shows 51% amino acid sequence identity to its human counterpart.

Literature References
PubMed ID Title Journal Year
17327220 Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK

Guo, B, Cheng, G

J Biol Chem 2007
17332413 Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

Tenoever, BR, Ng, SL, Chua, MA, McWhirter, SM, Garcia-Sastre, A, Maniatis, T

Science 2007
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Recruitment of TANK to TRAF6 (Homo sapiens)
Authored
Shamovsky, V  (2011-01-05)
Reviewed
Garapati, P V  (2011-05-16)
Created
Shamovsky, V  (2011-03-10)