Reactome | TRAF3-dependent IRF activation pathway

TRAF3-dependent IRF activation pathway

Stable Identifier

R-HSA-918233

Type

Pathway

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

MAVS via its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7.

Literature References

PubMed ID	Title	Journal	Year
17190786	Antiviral signaling through pattern recognition receptors Kawai, T, Akira, S	J Biochem	2007
16306936	Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response Oganesyan, G, Saha, SK, Guo, B, He, JQ, Shahangian, A, Zarnegar, B, Perry, A, Cheng, G	Nature	2006