Reactome | Dimerization of Phospho-IRF3

Dimerization of Phospho-IRF3

Stable Identifier

R-GGA-434027

Type

Reaction [binding]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Innate Immune System (Gallus gallus)

- RLR (RIG-like receptor) mediated induction of IFN alpha/beta (Gallus gallus)
  - TRAF mediated activation of IRF (Gallus gallus)
    - Dimerization of Phospho-IRF3 (Gallus gallus)
- Toll-like receptors (TLR) cascades (Gallus gallus)
  - TLR3 cascade (Gallus gallus)
    - IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3 (Gallus gallus)
      - Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK (Gallus gallus)
        
        Dimerization of Phospho-IRF3 (Gallus gallus)
      - Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 (Gallus gallus)
        
        Dimerization of Phospho-IRF3 (Gallus gallus)

General

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Phosphorylation results in IRF-3 dimerization and removal of an autoinhibitory structure to allow interaction with the coactivators CBP/p300.

Literature References

PubMed ID	Title	Journal	Year
14555995	X-ray crystal structure of IRF-3 and its functional implications Takahasi, K, Suzuki, NN, Horiuchi, M, Mori, M, Suhara, W, Okabe, Y, Fukuhara, Y, Terasawa, H, Akira, S, Fujita, T, Inagaki, F	Nat Struct Biol	2003