Recruitment of IRF to activated TBK1/IKK epsilon

Stable Identifier
Reaction [binding]
Gallus gallus
Related Species
Infectious bronchitis virus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In mammals, IRF3 and IRF7 (IRF3/IRF7) are the two major members of the interferon regulatory factor (IRF) family, involved in regulation of the pathogen-induced IFN gene expression.

Cormican et al (2009) reported that avian species lack the IRF3 gene. Indeed, bioinformatics analysis of chicken genome has identified IRF family member that is referred to as IRF3 or IRF7 depending on database reffered. Although the overall sequence shows high level of homology with IRF7 from other species, the specific activation sites of mammalian IRF3 are conserved in the chicken IRF ortholog.

In this project chicken IRF is annotated as counterpart of the mammalian IRF3.

Literature References
PubMed ID Title Journal Year
12692549 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, KA, McWhirter, SM, Faia, KL, Rowe, DC, Latz, E, Golenbock, DT, Coyle, AJ, Liao, SM, Maniatis, T

Nat Immunol 2003
16153868 VISA is an adapter protein required for virus-triggered IFN-beta signaling

Xu, LG, Wang, YY, Han, KJ, Li, LY, Zhai, Z, Shu, HB

Mol Cell 2005
Participant Of
Inferred From