Reactome | TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex

TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex

Stable Identifier

R-GGA-1227893

Type

Reaction [omitted]

Species

Gallus gallus

Related Species

Infectious bronchitis virus

Compartment

mitochondrial outer membrane, cytosol

ReviewStatus

5/5

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TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex

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TRAFs are E3 ubiquitin ligases that catalyse Lys63-polyubquitination of associated target proteins and possibly on themselves.
Virus- triggered Lys63-polyubiquitination of TRAF3/ or TRAF6 was shown to be essential for induction of IFN production [Mao AP et al 2010]. Furthermore, Kayagaki et al. demonstrated that deubiquitinating enzyme A (DUBA) specifically removed Lys63-linked polyubiquitin chains from TRAF3, resulting in its dissociation from the IFN signaling complex [Kayagaki N et al 2007].

Literature References

PubMed ID	Title	Journal	Year
17135271	Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation Lamothe, B, Besse, A, Campos, AD, Webster, WK, Wu, H, Darnay, BG	J Biol Chem	2007
19465916	E2 interaction and dimerization in the crystal structure of TRAF6 Yin, Q, Lin, SC, Lamothe, B, Lu, M, Lo, YC, Hura, G, Zheng, L, Rich, RL, Campos, AD, Myszka, DG, Lenardo, MJ, Darnay, BG, Wu, H	Nat Struct Mol Biol	2009
19675569	Direct activation of protein kinases by unanchored polyubiquitin chains Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ	Nature	2009