Reactome | PI3K alpha [cytosol]

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PI3K alpha [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-RNO-9927349] Class 1A PI3Ks [cytosol] - Rattus norvegicus
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9632399] Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] - Rattus norvegicus [Complex:R-RNO-205177] PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] - Rattus norvegicus [Complex:R-RNO-1562561] PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2 - Rattus norvegicus [Reaction:R-RNO-9021660] PI3K binds membrane-associated estrogen receptors - Rattus norvegicus [Reaction:R-RNO-416358] G alpha (q) inhibits PI3K alpha - Rattus norvegicus [Reaction:R-RNO-205262] Direct recruitment of PI3K to p-KIT - Rattus norvegicus [Reaction:R-RNO-114542] RAC1,RAC2,RHOG activate PI3K - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10112933
displayName	PI3K alpha [cytosol]
hasComponent	[CandidateSet:R-RNO-391342] PI3K-regulatory subunits [cytosol] [EntityWithAccessionedSequence:R-RNO-74787] Pik3ca [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-198379] PI3K alpha [cytosol] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-RNO-508248] p85-containing Class 1A PI3Ks [cytosol] - Rattus norvegicus [DefinedSet:R-RNO-437157] PI3K alpha, beta, gamma [cytosol] - Rattus norvegicus [CandidateSet:R-RNO-9014425] RAC2 plasma membrane effectors [cytosol] - Rattus norvegicus [CandidateSet:R-RNO-9013178] RAC1 effectors [cytosol] - Rattus norvegicus
name	PI3K alpha
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-198379
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasMember)	[CandidateSet:R-RNO-9014425] RAC2 plasma membrane effectors [cytosol] [CandidateSet:R-RNO-9013178] RAC1 effectors [cytosol] [DefinedSet:R-RNO-508248] p85-containing Class 1A PI3Ks [cytosol] [DefinedSet:R-RNO-437157] PI3K alpha, beta, gamma [cytosol]
(input)	[Reaction:R-RNO-1562641] Indirect recruitment of PI3K to KIT via p(Y)-GAB2 [Reaction:R-RNO-9021660] PI3K binds membrane-associated estrogen receptors [Reaction:R-RNO-416358] G alpha (q) inhibits PI3K alpha [Reaction:R-RNO-205262] Direct recruitment of PI3K to p-KIT [Reaction:R-RNO-114542] RAC1,RAC2,RHOG activate PI3K
(hasComponent)	[Complex:R-RNO-1562561] PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] [Complex:R-RNO-9632399] Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] [Complex:R-RNO-416356] G-protein alpha (q/11):PI3K alpha [plasma membrane] [Complex:R-RNO-205177] PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] [Complex:R-RNO-114540] RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] [Complex:R-RNO-9021654] ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane]
(hasCandidate)	[CandidateSet:R-RNO-9927349] Class 1A PI3Ks [cytosol]
(inferredTo)	[Complex:R-HSA-198379] PI3K alpha [cytosol]

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