Reactome | Pik3ca [cytosol]

Pik3ca [cytosol]

Stable Identifier

R-RNO-74787

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

PIK3CA, A0A0G2K344

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - RET signaling (Rattus norvegicus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Costimulation by the CD28 family (Rattus norvegicus)
    - CD28 co-stimulation (Rattus norvegicus)
      - CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        PI3K binds CD28 (Rattus norvegicus)
        
        CD28:PI3K [plasma membrane] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
    - PI3K binds ICOS (Rattus norvegicus)
      - ICOS:PI3K [plasma membrane] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
  - TCR signaling (Rattus norvegicus)
    - Downstream TCR signaling (Rattus norvegicus)
      - PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - Recruitment of PI3K to plasma membrane (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
- Cytokine Signaling in Immune system (Rattus norvegicus)
  - FLT3 Signaling (Rattus norvegicus)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - Pik3ca [cytosol] (Rattus norvegicus)
    - Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)
      - Pik3ca [cytosol] (Rattus norvegicus)
      - active FLT3:p-Y GRB10:PI3K [plasma membrane] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-2 family signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - 14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - Regulation of signaling by CBL (Rattus norvegicus)
        
        CBL ubiquitinates PI3K (Rattus norvegicus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        PI3K alpha [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - DAP12 interactions (Rattus norvegicus)
    - DAP12 signaling (Rattus norvegicus)
      - PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
  - Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
      - PI3K associates with phosphorylated GAB2 (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Role of phospholipids in phagocytosis (Rattus norvegicus)
      - PI3K binds to p-6Y-SYK (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
      - PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)
        
        PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
        
        PI3K [cytosol] (Rattus norvegicus)
        
        PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
        
        Pik3ca [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2K344 Pik3ca

Gene Names

Pik3ca

Chain

chain:1-1068

Reference Genes

BioGPS Gene:170911 Pik3ca

ENSEMBL:ENSRNOG00000056371 Pik3ca

KEGG Gene (Rattus norvegicus):170911 Pik3ca

Monarch:170911 Pik3ca

NCBI Gene:170911 Pik3ca

Reference Transcript

RefSeq:NM_133399.2 Pik3ca

Other Identifiers

10814726

10937594

1374232_at

1379041_at

1382366_at

1389143_at

1393499_at

170911

17737691

17876861

5621297

5665132

5670270

5681832

5684821

5707500

5801925

5839031

5847471

5880865

5921613

5951100

5955775

5981413

6051191

6070820

6078563

6086404

6086931

6097004

6120159

6131452

6157433

6206254

6219585

6230129

6288633

6294026

6300420

6329747

6423255

6424400

6435436

6440099

6547607

6586942

6604237

6623058

6699536

6727554

6729176

6734785

A_42_P562984

A_44_P156468

A_64_P066438

A_64_P073033

A_64_P130410

GE1148762

GE1182666

GE1206988

GE19439

GO:0000166

GO:0001525

GO:0001889

GO:0001932

GO:0003674

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005942

GO:0005943

GO:0005944

GO:0005975

GO:0006006

GO:0006091

GO:0006259

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006909

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0010468

GO:0010629

GO:0014065

GO:0014870

GO:0016020

GO:0016192

GO:0016301

GO:0016303

GO:0016310

GO:0016477

GO:0016740

GO:0030027

GO:0030234

GO:0030295

GO:0032147

GO:0032991

GO:0033138

GO:0034641

GO:0035004

GO:0035005

GO:0036092

GO:0040007

GO:0040011

GO:0040014

GO:0042592

GO:0043167

GO:0043201

GO:0043457

GO:0043491

GO:0043524

GO:0043560

GO:0044029

GO:0044281

GO:0046854

GO:0046934

GO:0048015

GO:0048646

GO:0048661

GO:0048856

GO:0048870

GO:0052742

GO:0052812

GO:0060612

GO:0071333

GO:0071548

GO:0097009

GO:1903544

GO:2000270

GO:2000653

GO:2000811

ILMN_1352006

PH_rn_0006374

rc_AA964375_at

rc_AA997895_at

rc_AI030797_at

Participant Of

input

hasComponent

hasMember

PI3K-catalytic subunit [cytosol]

Other forms of this molecule

Pik3ca [cytosol]

Inferred From

PIK3CA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_596890.2

IntEnz

2.7.1.153, 2.7.11.1

Ensembl

ENSRNOP00000072496, ENSRNOT00000083720, ENSRNOG00000056371

PRO

A0A0G2K344

RGD

620916

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