Reactome | PIK3CA:PIK3R1 [cytosol]

Schema > Complex > Entries

PIK3CA:PIK3R1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-1250373] PI3K:p-ERBB4cyt1 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-8851953] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] - Rattus norvegicus [Complex:R-RNO-9028508] BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-8851954] Phosphorylated GAB1 recruits PI3K to MET - Rattus norvegicus [Reaction:R-RNO-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - Rattus norvegicus [Reaction:R-RNO-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers - Rattus norvegicus [Reaction:R-RNO-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Rattus norvegicus [Reaction:R-RNO-177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - Rattus norvegicus [Reaction:R-RNO-1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10120320
displayName	PIK3CA:PIK3R1 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-RNO-74787] Pik3ca [cytosol] [EntityWithAccessionedSequence:R-RNO-74789] Pik3r1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-1806218] PIK3CA:PIK3R1 [cytosol] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-RNO-9012640] PI3K alpha, gamma [cytosol] - Rattus norvegicus
name	PIK3CA:PIK3R1
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1806218
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasMember)	[DefinedSet:R-RNO-9012640] PI3K alpha, gamma [cytosol] [DefinedSet:R-RNO-1806233] PIK3C(1) [cytosol] [DefinedSet:R-RNO-1806189] PIK3(2) [cytosol]
(activeUnit)	[CatalystActivity:10198505] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane]
(input)	[Reaction:R-RNO-8851954] Phosphorylated GAB1 recruits PI3K to MET [Reaction:R-RNO-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer [Reaction:R-RNO-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers [Reaction:R-RNO-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-RNO-177927] PI3K binds to EGF:EGFR:GRB2:GAB1 [Reaction:R-RNO-1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
(hasComponent)	[Complex:R-RNO-8851953] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] [Complex:R-RNO-9603404] NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] [Complex:R-RNO-1250373] PI3K:p-ERBB4cyt1 [plasma membrane] [Complex:R-RNO-9028508] BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] [Complex:R-RNO-179791] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] [Complex:R-RNO-1306974] NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane]
(inferredTo)	[Complex:R-HSA-1806218] PIK3CA:PIK3R1 [cytosol]

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