Reactome | Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA

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Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180970
displayName	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
eventOf	[Pathway:R-RNO-5654695] PI-3K cascade:FGFR2 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
input	[Complex:R-RNO-5654194] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-74787] Pik3ca [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
output	[Complex:R-RNO-5654192] Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
precedingEvent	[Reaction:R-RNO-5654620] Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5654622
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5654695] PI-3K cascade:FGFR2
(precedingEvent)	[Reaction:R-RNO-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA

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