Reactome | VEGFA-VEGFR2 Pathway

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VEGFA-VEGFR2 Pathway Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099541
displayName	VEGFA-VEGFR2 Pathway
eventOf	[Pathway:R-MMU-194138] Signaling by VEGF - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-9691215] VEGFA-165 dimer binds VEGFR2 dimer - Mus musculus [Reaction:R-MMU-9679477] VEGFA-165 dimer binds VEGFA inhibitors - Mus musculus [Reaction:R-MMU-4420117] VEGFR2 autophosphorylates - Mus musculus [Reaction:R-MMU-4420099] p-6Y-VEGFR2 binds SHB - Mus musculus [Reaction:R-MMU-4420128] SRC-1 phosphorylates SHB - Mus musculus [Reaction:R-MMU-4420083] PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 - Mus musculus [Reaction:R-MMU-5218642] PTK2 autophosphorylates - Mus musculus [Reaction:R-MMU-5218645] SRC-1 binds p-Y397-PTK2 - Mus musculus [Reaction:R-MMU-5218640] SRC-1 phosphorylates p-Y397-PTK2 - Mus musculus [Reaction:R-MMU-5218818] Integrin alphaVbeta3 binds p-6Y-VEGFR2 - Mus musculus [Reaction:R-MMU-5218643] HSP90AA1 binds p-6Y-VEGFR2 - Mus musculus [Reaction:R-MMU-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Mus musculus [Reaction:R-MMU-5228992] ROCK1,ROCK2 are activated - Mus musculus [Reaction:R-MMU-5218826] Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 - Mus musculus [Reaction:R-MMU-5218836] PTK2beta binds alphaVbeta3 - Mus musculus [Reaction:R-MMU-5218830] SRC-1 phosphorylates PTK2-beta - Mus musculus [Reaction:R-MMU-5218851] p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 - Mus musculus [Reaction:R-MMU-5218838] PXN binds p-6Y,S732-PTK2 - Mus musculus [Reaction:R-MMU-5218809] PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 - Mus musculus [Reaction:R-MMU-5218822] CRK binds BCAR1 and or PXN - Mus musculus [Reaction:R-MMU-5218811] DOCK180:ELMO binds CRK - Mus musculus [Reaction:R-MMU-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Mus musculus [Reaction:R-MMU-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Mus musculus [Reaction:R-MMU-4420107] p-6Y-VEGFR2 binds SHC-transforming protein 2 - Mus musculus [Reaction:R-MMU-4420143] p-6Y-VEGFR2 binds SH2D2A - Mus musculus [Reaction:R-MMU-4420140] SRC1-1 binds SH2D2A and is recruited to VEGFR2 - Mus musculus [Reaction:R-MMU-4420206] Phosphorylation of SRC-1 - Mus musculus [Reaction:R-MMU-5357432] AXL binds SRC-1 - Mus musculus [Reaction:R-MMU-5357429] AXL autophosphorylates on Y779 and Y821 - Mus musculus [Reaction:R-MMU-5357479] p-AXL binds PI3K - Mus musculus [Reaction:R-MMU-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-5218820] Src kinases phosphorylate VAV - Mus musculus [Reaction:R-MMU-8951586] p-VAV family:PIP3 binds RAC1:GDP - Mus musculus [Reaction:R-MMU-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Mus musculus [Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability - Mus musculus [Reaction:R-MMU-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Mus musculus [Reaction:R-MMU-5218841] NADPH oxidase 2 generates superoxide from oxygen - Mus musculus [Reaction:R-MMU-5218815] p-6Y-VEGFR2 binds NCK - Mus musculus [Reaction:R-MMU-5218824] p-6Y-VEGFR2 binds FYN - Mus musculus [Reaction:R-MMU-5218806] FYN autophosphorylates - Mus musculus [Reaction:R-MMU-5218854] p-Y420-FYN is phosphorylated on S21 - Mus musculus [Reaction:R-MMU-5218847] PAK2 binds NCK - Mus musculus [Reaction:R-MMU-5218832] CDC42:GTP binds PAK2 - Mus musculus [Reaction:R-MMU-5218814] PAK2 autophorylates - Mus musculus [Reaction:R-MMU-5218812] FYN phosphorylates PAK2 - Mus musculus [BlackBoxEvent:R-MMU-5218804] p38 MAPK activation by VEGFR - Mus musculus [Reaction:R-MMU-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 - Mus musculus [BlackBoxEvent:R-MMU-5218916] p-MAPK2/3 phosphorylates HSP27 - Mus musculus [Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation - Mus musculus
inferredFrom	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	VEGFA-VEGFR2 Pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-4420097
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(hasEvent)	[Pathway:R-MMU-194138] Signaling by VEGF

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