Reactome | Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

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Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 Show undefined attributes

catalystActivity	[CatalystActivity:10052945] protein serine/threonine kinase activity of RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10052947
displayName	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
eventOf	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5218851] p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 - Mus musculus
inferredFrom	[Reaction:R-HSA-5218826] Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-5218637] VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-5218775] VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-5228992] ROCK1,ROCK2 are activated - Mus musculus [Reaction:R-MMU-5218643] HSP90AA1 binds p-6Y-VEGFR2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5218826
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-MMU-5218851] p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407
(inferredTo)	[Reaction:R-HSA-5218826] Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732

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