Reactome | PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

Schema > Reaction > Entries

PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 Show undefined attributes

catalystActivity	[CatalystActivity:10052844] protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10052846
displayName	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118
eventOf	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5218822] CRK binds BCAR1 and or PXN - Mus musculus
inferredFrom	[Reaction:R-HSA-5218809] PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-5218781] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-5218756] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
precedingEvent	[Reaction:R-MMU-5218838] PXN binds p-6Y,S732-PTK2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5218809
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-MMU-5218822] CRK binds BCAR1 and or PXN
(inferredTo)	[Reaction:R-HSA-5218809] PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

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