Reactome | CRK binds BCAR1 and or PXN

Schema > Reaction > Entries

CRK binds BCAR1 and or PXN Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10052928
displayName	CRK binds BCAR1 and or PXN
eventOf	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5218811] DOCK180:ELMO binds CRK - Mus musculus
inferredFrom	[Reaction:R-HSA-5218822] CRK binds BCAR1 and or PXN - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-2980677] Crk [cytosol] [DefinedSet:R-MMU-5218759] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CRK binds BCAR1 and or PXN
output	[Complex:R-MMU-5218765] VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane]
precedingEvent	[Reaction:R-MMU-5218809] PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5218822
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-MMU-5218811] DOCK180:ELMO binds CRK
(inferredTo)	[Reaction:R-HSA-5218822] CRK binds BCAR1 and or PXN