Reactome | p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3

Schema > Reaction > Entries

p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 Show undefined attributes

catalystActivity	[CatalystActivity:10000306] protein serine/threonine kinase activity of Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10000308
displayName	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3
eventOf	[Pathway:R-MMU-171007] p38MAPK events - Mus musculus [Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-5218916] p-MAPK2/3 phosphorylates HSP27 - Mus musculus
inferredFrom	[Reaction:R-HSA-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-MMU-187699] MAPKAP kinase [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-MMU-187726] p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol]
precedingEvent	[BlackBoxEvent:R-MMU-5218804] p38 MAPK activation by VEGFR - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-187688
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway [Pathway:R-MMU-171007] p38MAPK events
(precedingEvent)	[BlackBoxEvent:R-MMU-5218916] p-MAPK2/3 phosphorylates HSP27
(inferredTo)	[Reaction:R-HSA-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3

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