Reactome | Phosphorylation of SRC-1

Schema > Reaction > Entries

Phosphorylation of SRC-1 Show undefined attributes

catalystActivity	[CatalystActivity:10050858] protein tyrosine kinase activity of VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10050860
displayName	Phosphorylation of SRC-1
eventOf	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5357432] AXL binds SRC-1 - Mus musculus
inferredFrom	[Reaction:R-HSA-4420206] Phosphorylation of SRC-1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-4420169] VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of SRC-1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-5218788] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-4420140] SRC1-1 binds SH2D2A and is recruited to VEGFR2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-4420206
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-MMU-5357432] AXL binds SRC-1
(inferredTo)	[Reaction:R-HSA-4420206] Phosphorylation of SRC-1

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