Reactome | SRC-1 phosphorylates PTK2-beta

Schema > Reaction > Entries

SRC-1 phosphorylates PTK2-beta Show undefined attributes

catalystActivity	[CatalystActivity:10052761] protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10052970
displayName	SRC-1 phosphorylates PTK2-beta
eventOf	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5218851] p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 - Mus musculus
inferredFrom	[Reaction:R-HSA-5218830] SRC-1 phosphorylates PTK2-beta - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-5218787] VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SRC-1 phosphorylates PTK2-beta
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-5218778] VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane]
precedingEvent	[Reaction:R-MMU-5218836] PTK2beta binds alphaVbeta3 - Mus musculus [Reaction:R-MMU-5218645] SRC-1 binds p-Y397-PTK2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5218830
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-MMU-5218851] p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407
(inferredTo)	[Reaction:R-HSA-5218830] SRC-1 phosphorylates PTK2-beta