Reactome | Maturation of TCA enzymes and regulation of TCA cycle

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Maturation of TCA enzymes and regulation of TCA cycle Show undefined attributes

authored	[InstanceEdit:9854297] Stephan, Ralf, 2023-11-25
compartment	[Compartment:5462] mitochondrion
created	[InstanceEdit:9854323] Stephan, Ralf, 2023-11-25
dbId	9854311
displayName	Maturation of TCA enzymes and regulation of TCA cycle
doi	10.3180/R-HSA-9854311.1
edited	[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15 [InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
eventOf	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9854315] CSKMT methylates Citrate Synthase - Homo sapiens [Reaction:R-HSA-9854368] ROS,RNS oxidize ACO2:4Fe-4S - Homo sapiens [Reaction:R-HSA-9854405] Frataxin transfers Fe2+ to ACO2 - Homo sapiens [Reaction:R-HSA-9854415] ACAT1 tetramer acetylates IDH2 dimer - Homo sapiens [Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Homo sapiens [Reaction:R-HSA-9854672] FAD attaches to SDHA - Homo sapiens [Reaction:R-HSA-9854961] SDHAF4 binds to FAD-SDHA - Homo sapiens [BlackBoxEvent:R-HSA-9854984] Transfer of Fe-S clusters to SDHB - Homo sapiens [Reaction:R-HSA-9855212] SDHA binds to SDHB - Homo sapiens [Reaction:R-HSA-9855252] SDHA:SDHB binds to SDHC:SDHD - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9855260] Regulation and function of the mammalian tricarboxylic acid�cycle
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Maturation of TCA enzymes and regulation of TCA cycle
orthologousEvent	[Pathway:R-DRE-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Danio rerio [Pathway:R-PFA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Plasmodium falciparum [Pathway:R-SCE-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Saccharomyces cerevisiae [Pathway:R-SPO-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Schizosaccharomyces pombe [Pathway:R-DDI-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Dictyostelium discoideum [Pathway:R-CEL-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Caenorhabditis elegans [Pathway:R-DME-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Drosophila melanogaster [Pathway:R-GGA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Gallus gallus [Pathway:R-XTR-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Xenopus tropicalis [Pathway:R-SSC-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Sus scrofa [Pathway:R-BTA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Bos taurus [Pathway:R-CFA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Canis familiaris [Pathway:R-RNO-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Rattus norvegicus [Pathway:R-MMU-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Mus musculus
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9854311
summation	[Summation:9855268] (Citrate-synthase)-lysyl-methyltransferase (CSKMT, METTL12) ...

Referrals

(hasEncapsulatedEvent)	[Pathway:R-HSA-611105] Respiratory electron transport
(hasEvent)	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)

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