Reactome | ACAT1 tetramer acetylates IDH2 dimer

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ACAT1 tetramer acetylates IDH2 dimer Show undefined attributes

authored	[InstanceEdit:9854399] Stephan, Ralf, 2023-11-26
catalystActivity	[CatalystActivity:9854426] acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9854421] Stephan, Ralf, 2023-11-26
crossReference	[DatabaseIdentifier:9854409] RHEA:45948
dbId	9854415
displayName	ACAT1 tetramer acetylates IDH2 dimer
edited	[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15
eventOf	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [Complex:R-HSA-450982] IDH2 dimer [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9854428] Regulation of cellular metabolism by protein lysine acetylation [LiteratureReference:9854422] Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ACAT1 tetramer acetylates IDH2 dimer
orthologousEvent	[Reaction:R-DRE-9854415] ACAT1 tetramer acetylates IDH2 dimer - Danio rerio [Reaction:R-PFA-9854415] ACAT1 tetramer acetylates IDH2 dimer - Plasmodium falciparum [Reaction:R-CEL-9854415] ACAT1 tetramer acetylates IDH2 dimer - Caenorhabditis elegans [Reaction:R-GGA-9854415] ACAT1 tetramer acetylates IDH2 dimer - Gallus gallus [Reaction:R-SSC-9854415] ACAT1 tetramer acetylates IDH2 dimer - Sus scrofa [Reaction:R-BTA-9854415] ACAT1 tetramer acetylates IDH2 dimer - Bos taurus [Reaction:R-CFA-9854415] ACAT1 tetramer acetylates IDH2 dimer - Canis familiaris [Reaction:R-RNO-9854415] ACAT1 tetramer acetylates IDH2 dimer - Rattus norvegicus [Reaction:R-MMU-9854415] ACAT1 tetramer acetylates IDH2 dimer - Mus musculus
output	[Complex:R-HSA-9854462] AcK-IDH2 dimer [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9854415
summation	[Summation:9854411] All enzymes of the TCA cycle are highly acetylated at multip...

Referrals

(hasEvent)	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(precedingEvent)	[Reaction:R-HSA-9854463] SIRT3 deacetylates AcK-IDH2 dimer