Reactome | SDHA:SDHB binds to SDHC:SDHD

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SDHA:SDHB binds to SDHC:SDHD Show undefined attributes

authored	[InstanceEdit:9855215] Stephan, Ralf, 2023-11-29
category	dissociation
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9855258] Stephan, Ralf, 2023-11-30
dbId	9855252
displayName	SDHA:SDHB binds to SDHC:SDHD
edited	[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15
eventOf	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-163213] Transfer of electrons through the succinate dehydrogenase complex - Homo sapiens [Reaction:R-HSA-70994] SDH complex dehydrogenates succinate - Homo sapiens
input	[Complex:R-HSA-9855213] FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3 [mitochondrial matrix] [Complex:R-HSA-9853501] SDHC:SDHD:heme b [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9855014] Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes [LiteratureReference:9854982] Protein-mediated assembly of succinate dehydrogenase and its cofactors [LiteratureReference:9855253] Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit [LiteratureReference:9855256] Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	SDHA:SDHB binds to SDHC:SDHD
orthologousEvent	[Reaction:R-XTR-9855252] SDHA:SDHB binds to SDHC:SDHD - Xenopus tropicalis [Reaction:R-DRE-9855252] SDHA:SDHB binds to SDHC:SDHD - Danio rerio [Reaction:R-SSC-9855252] SDHA:SDHB binds to SDHC:SDHD - Sus scrofa [Reaction:R-BTA-9855252] SDHA:SDHB binds to SDHC:SDHD - Bos taurus [Reaction:R-RNO-9855252] SDHA:SDHB binds to SDHC:SDHD - Rattus norvegicus [Reaction:R-MMU-9855252] SDHA:SDHB binds to SDHC:SDHD - Mus musculus
output	[Complex:R-HSA-70990] SDH complex [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-HSA-9854988] SDHAF1 [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9855015] SDHAF3 [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9855212] SDHA binds to SDHB - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9855252
summation	[Summation:9855255] After translation in cytosol and translocation to the mitoch...

Referrals

(hasEvent)	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(precedingEvent)	[Reaction:R-HSA-163213] Transfer of electrons through the succinate dehydrogenase complex [Reaction:R-HSA-70994] SDH complex dehydrogenates succinate