Reactome | SDHA binds to SDHB

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SDHA binds to SDHB Show undefined attributes

authored	[InstanceEdit:9855013] Stephan, Ralf, 2023-11-29
catalystActivity	[CatalystActivity:9861211] protein folding chaperone activity of SDHAF4 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9855215] Stephan, Ralf, 2023-11-29
dbId	9855212
displayName	SDHA binds to SDHB
edited	[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15
eventOf	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9855252] SDHA:SDHB binds to SDHC:SDHD - Homo sapiens
input	[Complex:R-HSA-9854960] FAD-SDHA:SDHAF4 [mitochondrial matrix] [Complex:R-HSA-9854993] SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHAF1:SDHAF3 [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9854982] Protein-mediated assembly of succinate dehydrogenase and its cofactors [LiteratureReference:9855018] The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	SDHA binds to SDHB
orthologousEvent	[Reaction:R-XTR-9855212] SDHA binds to SDHB - Xenopus tropicalis [Reaction:R-DRE-9855212] SDHA binds to SDHB - Danio rerio [Reaction:R-SSC-9855212] SDHA binds to SDHB - Sus scrofa [Reaction:R-BTA-9855212] SDHA binds to SDHB - Bos taurus [Reaction:R-MMU-9855212] SDHA binds to SDHB - Mus musculus
output	[Complex:R-HSA-9855213] FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3 [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9854972] SDHAF4 [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-9854984] Transfer of Fe-S clusters to SDHB - Homo sapiens [Reaction:R-HSA-9854961] SDHAF4 binds to FAD-SDHA - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861366] Hill, David P, 2024-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9855212
summation	[Summation:9855214] The matured SDH subunits A and B (SDHA, SDHB) bind, releasin...

Referrals

(hasEvent)	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(precedingEvent)	[Reaction:R-HSA-9855252] SDHA:SDHB binds to SDHC:SDHD