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Schema
>
Pathway
>
Entries
Citric acid cycle (TCA cycle)
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authored
[InstanceEdit:71404] Birney, E, 2003-01-28 00:00:00
compartment
[Compartment:5462] mitochondrion
dbId
71403
displayName
Citric acid cycle (TCA cycle)
doi
10.3180/R-HSA-71403.5
edited
[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf
[Pathway:R-HSA-1428517] Aerobic respiration and respiratory electron transport - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:12759] tricarboxylic acid cycle
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-70975] CS acetylates OA to citrate - Homo sapiens
[Reaction:R-HSA-70971] ACO2 isomerizes citrate - Homo sapiens
[Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate - Homo sapiens
[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate - Homo sapiens
[Reaction:R-HSA-450971] NNT dimer transfers proton from NADPH to NAD+ - Homo sapiens
[Pathway:R-HSA-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Homo sapiens
[Reaction:R-HSA-70997] SUCLG1/A2 cleaves succinyl-CoA - Homo sapiens
[Reaction:R-HSA-71775] SUCLG1/G2 cleaves succinyl-CoA - Homo sapiens
[Reaction:R-HSA-70994] SDH complex dehydrogenates succinate - Homo sapiens
[Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate - Homo sapiens
[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens
[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:198401] The oxidation of pyruvate in pigeon breast muscle
[LiteratureReference:198419] The formation of citric and alpha-ketoglutaric acids in the mammalian body
[LiteratureReference:198393] The pursuit of a hobby
[LiteratureReference:9763394] Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
[LiteratureReference:9763373] Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1? in cancer
[LiteratureReference:9853575] Emerging Role of TCA Cycle-Related Enzymes in Human Diseases
[LiteratureReference:9853573] Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion
[LiteratureReference:9853584] Reductive carboxylation supports redox homeostasis during anchorage-independent growth
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
Citric acid cycle (TCA cycle)
orthologousEvent
[Pathway:R-RNO-71403] Citric acid cycle (TCA cycle) - Rattus norvegicus
[Pathway:R-MMU-71403] Citric acid cycle (TCA cycle) - Mus musculus
[Pathway:R-SSC-71403] Citric acid cycle (TCA cycle) - Sus scrofa
[Pathway:R-DRE-71403] Citric acid cycle (TCA cycle) - Danio rerio
[Pathway:R-XTR-71403] Citric acid cycle (TCA cycle) - Xenopus tropicalis
[Pathway:R-GGA-71403] Citric acid cycle (TCA cycle) - Gallus gallus
[Pathway:R-DME-71403] Citric acid cycle (TCA cycle) - Drosophila melanogaster
[Pathway:R-CEL-71403] Citric acid cycle (TCA cycle) - Caenorhabditis elegans
[Pathway:R-DDI-71403] Citric acid cycle (TCA cycle) - Dictyostelium discoideum
[Pathway:R-SPO-71403] Citric acid cycle (TCA cycle) - Schizosaccharomyces pombe
[Pathway:R-SCE-71403] Citric acid cycle (TCA cycle) - Saccharomyces cerevisiae
[Pathway:R-PFA-71403] Citric acid cycle (TCA cycle) - Plasmodium falciparum
[Pathway:R-BTA-71403] Citric acid cycle (TCA cycle) - Bos taurus
[Pathway:R-CFA-71403] Citric acid cycle (TCA cycle) - Canis familiaris
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2003-02-06
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised
[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-71403
summation
[Summation:71405] In the citric acid or tricarboxylic acid (TCA) cycle, the ac...
Referrals
(hasEvent)
[Pathway:R-HSA-1428517] Aerobic respiration and respiratory electron transport
(hasEncapsulatedEvent)
[Pathway:R-HSA-163200] Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
[Pathway:R-HSA-9856872] Malate-aspartate shuttle
[Pathway:R-HSA-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
[Pathway:R-HSA-8963691] Phenylalanine and tyrosine metabolism
[Pathway:R-HSA-425393] Transport of inorganic cations/anions and amino acids/oligopeptides
[Pathway:R-HSA-70268] Pyruvate metabolism
[Pathway:R-HSA-9857492] Protein lipoylation
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