Reactome | Maturation of TCA enzymes and regulation of TCA cycle

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Maturation of TCA enzymes and regulation of TCA cycle Show undefined attributes

compartment	[Compartment:5462] mitochondrion
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331969
displayName	Maturation of TCA enzymes and regulation of TCA cycle
eventOf	[Pathway:R-CFA-71403] Citric acid cycle (TCA cycle) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-9854315] CSKMT methylates Citrate Synthase - Canis familiaris [Reaction:R-CFA-9854368] ROS,RNS oxidize ACO2:4Fe-4S - Canis familiaris [Reaction:R-CFA-9854405] Frataxin transfers Fe2+ to ACO2 - Canis familiaris [Reaction:R-CFA-9854415] ACAT1 tetramer acetylates IDH2 dimer - Canis familiaris [Reaction:R-CFA-9854463] SIRT3 deacetylates AcK-IDH2 dimer - Canis familiaris [Reaction:R-CFA-9854672] FAD attaches to SDHA - Canis familiaris [Reaction:R-CFA-9854961] SDHAF4 binds to FAD-SDHA - Canis familiaris
inferredFrom	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Maturation of TCA enzymes and regulation of TCA cycle
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9854311
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-CFA-611105] Respiratory electron transport
(hasEvent)	[Pathway:R-CFA-71403] Citric acid cycle (TCA cycle)
(inferredTo)	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle

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