Reactome | FAD attaches to SDHA

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FAD attaches to SDHA Show undefined attributes

authored	[InstanceEdit:9854482] Stephan, Ralf, 2023-11-27
catalystActivity	[CatalystActivity:9956931] FAD binding activity of SDHA [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9854696] Stephan, Ralf, 2023-11-28
dbId	9854672
displayName	FAD attaches to SDHA
edited	[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15
eventOf	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9854961] SDHAF4 binds to FAD-SDHA - Homo sapiens
input	[SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9854690] SDHA [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9854676] How an assembly factor enhances covalent FAD attachment to the flavoprotein subunit of complex II [LiteratureReference:9854688] SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	FAD attaches to SDHA
orthologousEvent	[Reaction:R-SCE-9854672] FAD attaches to SDHA - Saccharomyces cerevisiae [Reaction:R-SPO-9854672] FAD attaches to SDHA - Schizosaccharomyces pombe [Reaction:R-DDI-9854672] FAD attaches to SDHA - Dictyostelium discoideum [Reaction:R-CEL-9854672] FAD attaches to SDHA - Caenorhabditis elegans [Reaction:R-DME-9854672] FAD attaches to SDHA - Drosophila melanogaster [Reaction:R-XTR-9854672] FAD attaches to SDHA - Xenopus tropicalis [Reaction:R-DRE-9854672] FAD attaches to SDHA - Danio rerio [Reaction:R-SSC-9854672] FAD attaches to SDHA - Sus scrofa [Reaction:R-BTA-9854672] FAD attaches to SDHA - Bos taurus [Reaction:R-CFA-9854672] FAD attaches to SDHA - Canis familiaris [Reaction:R-RNO-9854672] FAD attaches to SDHA - Rattus norvegicus [Reaction:R-MMU-9854672] FAD attaches to SDHA - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-70983] FAD-SDHA [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[Requirement:9854702] Requirement by 'SDHAF2 [mitochondrial matrix]' [PositiveRegulation:9854700] Positive regulation by 'FUMA [mitochondrial matrix]'
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15 [InstanceEdit:9963235] Hill, David P, 2025-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9854672
summation	[Summation:9854703] Flavin adenine dinucleotide (FAD) binds covalently and non-e...
updateTrackers	[UpdateTracker:9964723] Update Tracker - [Reaction:9854672] FAD attaches to SDHA - v94:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9964723] Update Tracker - [Reaction:9854672] FAD attaches to SDHA - v94:[removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(precedingEvent)	[Reaction:R-HSA-9854961] SDHAF4 binds to FAD-SDHA