Reactome | EGR2 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

EGR2 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9613167] RRAD gene:EGR2 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9613463] ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] - Homo sapiens [Complex:R-HSA-5617477] EGR2 at active HOXA2 chromatin [nucleoplasm] - Homo sapiens [Complex:R-HSA-5617671] MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-5617492] EGR2 (KROX20) activates HOXB2 expression - Homo sapiens [Reaction:R-HSA-9615638] EGR2 and SOX10 bind the MBP gene - Homo sapiens [Reaction:R-HSA-9621400] EGR2 and SREBF2 dimer bind SCD5 gene - Homo sapiens [Reaction:R-HSA-9614790] EGR2, SOX10 and SMARCA4 bind the MPZ gene - Homo sapiens [Reaction:R-HSA-9618559] EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene - Homo sapiens [BlackBoxEvent:R-HSA-5617484] EGR2 (KROX20) activates HOXA2 expression - Homo sapiens [Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions - Homo sapiens [Reaction:R-HSA-9619657] EGR2 and SOX10 bind the PRX gene - Homo sapiens [Reaction:R-HSA-9621406] EGR2 and SREBF2 dimer bind CYP51A1 gene - Homo sapiens [Reaction:R-HSA-9616116] EGR2 and SOX10 bind the MAG gene - Homo sapiens [Reaction:R-HSA-9621411] EGR2 and SREBF2(1-484) dimer bind HMGCR gene - Homo sapiens [BlackBoxEvent:R-HSA-5617661] MAFB:JUN and EGR2 activate HOXB3 expression - Homo sapiens [Reaction:R-HSA-9618725] SOX10, EGR2 and NAB proteins bind the GJB1 promoter - Homo sapiens
created	[InstanceEdit:977391] May, B, 2010-10-19
dbId	977385
displayName	EGR2 [nucleoplasm]
endCoordinate	476
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-977385] Egr2 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-977385] Egr2 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-977385] EGR2 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-977385] EGR2 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-977385] EGR2 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-977385-2] EGR2 [nucleoplasm] - Sus scrofa [DefinedSet:R-SSC-977385-3] Homologues of EGR2 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-977385] egr2b [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-977385] egr2 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-977385] KROX20 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-977385] sr [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-977385] egrh-1 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-977385-2] egrh-2 [nucleoplasm] - Caenorhabditis elegans [DefinedSet:R-CEL-977385-3] Homologues of EGR2 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-SCE-977385] CRZ1 [nucleoplasm] - Saccharomyces cerevisiae
memberOf	[DefinedSet:R-HSA-9612066] EGR1, EGR2,EGR4 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9612485] EGR1,2,3 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9613165] EGR1,EGR2 [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:5617501] May, Bruce, 2014-08-12
name	EGR2 EGR2 (KROX2) Early growth response protein 2 EGR2_HUMAN KROX20
negativelyRegulates	[NegativeGeneExpressionRegulation:R-HSA-6810147] Negative gene expression regulation by 'EGR2 [nucleoplasm]'
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-977394] Positive gene expression regulation by 'EGR2 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-9613760] EGR2 gene expression - Homo sapiens
referenceEntity	[ReferenceGeneProduct:54216] UniProt:P11161 EGR2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-977385
startCoordinate	1

Referrals

(hasComponent)	[Complex:R-HSA-5617477] EGR2 at active HOXA2 chromatin [nucleoplasm] [Complex:R-HSA-5617671] MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] [Complex:R-HSA-5617489] EGR2 at active HOXB2 chromatin [nucleoplasm] [Complex:R-HSA-9613463] ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] [Complex:R-HSA-9613167] RRAD gene:EGR2 [nucleoplasm] [Complex:R-HSA-9613187] RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] [Complex:R-HSA-9619633] PRX gene:EGR2:SOX10 [nucleoplasm] [Complex:R-HSA-9615629] MBP gene:EGR2:SOX10 [nucleoplasm] [Complex:R-HSA-9621358] SCD5 gene:EGR2:SREBF2 dimer [nucleoplasm] [Complex:R-HSA-9621347] CYP51A1 gene:EGR2:SREBF2 dimer [nucleoplasm] [Complex:R-HSA-9614793] MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm] [Complex:R-HSA-9618555] PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm] [Complex:R-HSA-9616114] MAG gene:EGR2:SOX10 [nucleoplasm] [Complex:R-HSA-9621351] HMGCR gene:EGR2:SREBF2 dimer [nucleoplasm] [Complex:R-HSA-9618726] GJB11 gene:SOX10:EGR2:NAB1,2 [nucleoplasm]
(input)	[BlackBoxEvent:R-HSA-5617484] EGR2 (KROX20) activates HOXA2 expression [BlackBoxEvent:R-HSA-5617661] MAFB:JUN and EGR2 activate HOXB3 expression [BlackBoxEvent:R-HSA-5617492] EGR2 (KROX20) activates HOXB2 expression [Reaction:R-HSA-9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions [Reaction:R-HSA-9619657] EGR2 and SOX10 bind the PRX gene [Reaction:R-HSA-9615638] EGR2 and SOX10 bind the MBP gene [Reaction:R-HSA-9621400] EGR2 and SREBF2 dimer bind SCD5 gene [Reaction:R-HSA-9621406] EGR2 and SREBF2 dimer bind CYP51A1 gene [Reaction:R-HSA-9614790] EGR2, SOX10 and SMARCA4 bind the MPZ gene [Reaction:R-HSA-9618559] EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene [Reaction:R-HSA-9616116] EGR2 and SOX10 bind the MAG gene [Reaction:R-HSA-9621411] EGR2 and SREBF2(1-484) dimer bind HMGCR gene [Reaction:R-HSA-9618725] SOX10, EGR2 and NAB proteins bind the GJB1 promoter
(output)	[BlackBoxEvent:R-HSA-9613760] EGR2 gene expression
(hasMember)	[DefinedSet:R-HSA-9612066] EGR1, EGR2,EGR4 [nucleoplasm] [DefinedSet:R-HSA-9612485] EGR1,2,3 [nucleoplasm] [DefinedSet:R-HSA-9613165] EGR1,EGR2 [nucleoplasm]
(activeUnit)	[PositiveGeneExpressionRegulation:R-HSA-5634079] Positive gene expression regulation by 'EGR2 at active HOXB2 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5634071] Positive gene expression regulation by 'EGR2 at active HOXA2 chromatin [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5634070] Positive gene expression regulation by 'MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm]' [NegativeRegulation:9613473] Negative regulation by 'ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm]' [PositiveGeneExpressionRegulation:9619644] Positive gene expression regulation by 'PRX gene:EGR2:SOX10 [nucleoplasm]' [PositiveGeneExpressionRegulation:9621374] Positive gene expression regulation by 'SCD5 gene:EGR2:SREBF2 dimer [nucleoplasm]' [PositiveGeneExpressionRegulation:9621368] Positive gene expression regulation by 'CYP51A1 gene:EGR2:SREBF2 dimer [nucleoplasm]' [PositiveGeneExpressionRegulation:9614782] Positive gene expression regulation by 'MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm]' [PositiveGeneExpressionRegulation:9615630] Positive gene expression regulation by 'MBP gene:EGR2:SOX10 [nucleoplasm]' [PositiveGeneExpressionRegulation:9616128] Positive gene expression regulation by 'MAG gene:EGR2:SOX10 [nucleoplasm]' [PositiveGeneExpressionRegulation:9621371] Positive gene expression regulation by 'HMGCR gene:EGR2:SREBF2 dimer [nucleoplasm]' [PositiveGeneExpressionRegulation:9620409] Positive gene expression regulation by 'EGR1,EGR2,EGR3:ARC gene [nucleoplasm]'
(regulator)	[PositiveGeneExpressionRegulation:R-HSA-977394] Positive gene expression regulation by 'EGR2 [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-6810147] Negative gene expression regulation by 'EGR2 [nucleoplasm]'

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