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EGR2 [nucleoplasm]
Stable Identifier
R-HSA-977385
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
EGR2 (KROX2), Early growth response protein 2, EGR2_HUMAN, KROX20
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
HOXA2 gene is transcribed (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
HOXB1 gene is transcribed (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
HOXB2 gene is transcribed (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
HOXB3 gene is transcribed (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of CEBPB in adipogenesis (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
Nervous system development (Homo sapiens)
EGR2 and SOX10-mediated initiation of Schwann cell myelination (Homo sapiens)
CYP51A1 gene expression (Homo sapiens)
CYP51A1 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 and SOX10 bind the MAG gene (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MAG gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 and SOX10 bind the MBP gene (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MBP gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 and SOX10 bind the PRX gene (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
PRX gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 and SREBF2 dimer bind CYP51A1 gene (Homo sapiens)
CYP51A1 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 and SREBF2 dimer bind SCD5 gene (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
SCD5 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
HMGCR gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 gene expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
HMGCR gene expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
HMGCR gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MAG gene expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MAG gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MBP gene expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MBP gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MPZ gene expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
PMP22 gene expression (Homo sapiens)
PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
PRX gene expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
PRX gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
SCD5 gene expression (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
SCD5 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
GJB11 gene:SOX10:EGR2:NAB1,2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
ARC gene expression (Homo sapiens)
EGR1,EGR2,EGR3:ARC gene [nucleoplasm] (Homo sapiens)
EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR binds ARC gene (Homo sapiens)
EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR1,EGR2,EGR3:ARC gene [nucleoplasm] (Homo sapiens)
EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR-dependent NAB2 gene expression (Homo sapiens)
NAB2 gene:EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR1, EGR2 bind the RRAD promoter (Homo sapiens)
EGR1,EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR1,EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR1,2,3 bind the NAB2 promoter (Homo sapiens)
EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
NAB2 gene:EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
RRAD gene:EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression (Homo sapiens)
EGR1, EGR2,EGR4 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene expression (Homo sapiens)
EGR1,EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR1,EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
EGR2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11161 EGR2
Gene Names
EGR2, KROX20
Chain
chain:1-476
Reference Genes
BioGPS Gene:1959 EGR2
COSMIC (genes):EGR2 EGR2
CTD Gene:1959 EGR2
dbSNP Gene:1959 EGR2
ENSEMBL:ENSG00000122877 EGR2
ENSEMBL_homo_sapiens_GENE:ENSG00000122877.18 EGR2
HGNC:3239 EGR2
KEGG Gene (Homo sapiens):1959 EGR2
Monarch:1959 EGR2
NCBI Gene:1959 EGR2
OMIM:129010 EGR2
UCSC:P11161 EGR2
Reference Transcript
RefSeq:NM_001136177.2 EGR2
RefSeq:NM_001136179.2 EGR2
RefSeq:NM_001136178.1 EGR2
RefSeq:NM_000399.4 EGR2
RefSeq:NM_001321037.1 EGR2
Other Identifiers
11722728_a_at
11734811_a_at
11756832_a_at
16714776
1959
3291602
3291603
3291604
3291605
3291606
3291611
3291612
3291613
3291614
37863_at
7933872
A_23_P46936
GE80912
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0003677
GO:0003682
GO:0003700
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006611
GO:0006886
GO:0006913
GO:0007420
GO:0007422
GO:0007611
GO:0007622
GO:0008045
GO:0010467
GO:0014037
GO:0014040
GO:0016740
GO:0016925
GO:0021569
GO:0021612
GO:0021659
GO:0021660
GO:0021665
GO:0021666
GO:0023052
GO:0030154
GO:0030278
GO:0031625
GO:0031643
GO:0032868
GO:0035284
GO:0035904
GO:0035914
GO:0036211
GO:0042552
GO:0043226
GO:0043231
GO:0043565
GO:0045444
GO:0045893
GO:0045944
GO:0046872
GO:0048168
GO:0048856
GO:0050877
GO:0061629
GO:0061665
GO:0071310
GO:0071837
GO:0140096
GO:0140110
GO:1990837
HMNXSV003008803
J04076_at
PH_hs_0000185
g9845523_3p_at
Participates
as a component of
MAFB:JUN and EGR2 at active HOXB3 chromatin [nucleoplasm] (Homo sapiens)
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
GJB11 gene:SOX10:EGR2:NAB1,2 [nucleoplasm] (Homo sapiens)
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
PRX gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
MBP gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
SCD5 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
CYP51A1 gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
MPZ gene:EGR2:SOX10:SMARCA4 [nucleoplasm] (Homo sapiens)
PMP22 gene:EGR2:SOX10:TEAD1:WWTR1,YAP1 [nucleoplasm] (Homo sapiens)
MAG gene:EGR2:SOX10 [nucleoplasm] (Homo sapiens)
HMGCR gene:EGR2:SREBF2 dimer [nucleoplasm] (Homo sapiens)
as an input of
MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)
EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)
EGR2 (KROX20) activates HOXA2 expression (Homo sapiens)
EGR2 and SOX10 bind the PRX gene (Homo sapiens)
EGR2 and SOX10 bind the MBP gene (Homo sapiens)
EGR2 and SREBF2 dimer bind SCD5 gene (Homo sapiens)
EGR2 and SREBF2 dimer bind CYP51A1 gene (Homo sapiens)
EGR2, SOX10 and SMARCA4 bind the MPZ gene (Homo sapiens)
EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)
EGR2 and SOX10 bind the MAG gene (Homo sapiens)
as an output of
EGR2 gene expression (Homo sapiens)
as a member of
EGR1, EGR2,EGR4 [nucleoplasm] (Homo sapiens)
EGR1,2,3 [nucleoplasm] (Homo sapiens)
EGR1,EGR2 [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
HOXB1 gene is transcribed
(Homo sapiens)
Positively
Expression of CEBPB in adipogenesis
(Homo sapiens)
Inferred To
egr2b [nucleoplasm]
(Danio rerio)
sr [nucleoplasm]
(Drosophila melanogaster)
egrh-2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of EGR2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of EGR2 [nucleoplasm]
(Sus scrofa)
egrh-1 [nucleoplasm]
(Caenorhabditis elegans)
Egr2 [nucleoplasm]
(Mus musculus)
Egr2 [nucleoplasm]
(Rattus norvegicus)
KROX20 [nucleoplasm]
(Gallus gallus)
CRZ1 [nucleoplasm]
(Saccharomyces cerevisiae)
EGR2 [nucleoplasm]
(Bos taurus)
EGR2 [nucleoplasm]
(Canis familiaris)
EGR2 [nucleoplasm]
(Sus scrofa)
egr2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000390.2
,
NP_001129649.1
,
NP_001129651.1
,
NP_001129650.1
,
NP_001307966.1
OpenTargets
ENSG00000122877
GeneCards
P11161
HPA
ENSG00000122877-EGR2
Ensembl
ENST00000242480
,
ENSG00000122877
,
ENSP00000242480
,
ENST00000637191
,
ENSP00000387634
,
ENST00000411732
,
ENSP00000490154
PRO
P11161
Pharos - Targets
P11161
Orphanet
15918
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