Reactome | ITCH [cytosol]

Schema > EntityWithAccessionedSequence > Entries

ITCH [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-976075] E3 ligases in proteasomal degradation [cytosol] - Homo sapiens
catalystActivities	[CatalystActivity:990525] ubiquitin protein ligase activity of ITCH [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5610562] NUMB:ITCH [cytosol] - Homo sapiens [Complex:R-HSA-9685173] 9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane] - Homo sapiens [Complex:R-HSA-1911544] Ub-NOTCH1:NUMB:ITCH [plasma membrane] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-9685195] SARS-CoV-1 9b recruits ITCH to MAVS - Homo sapiens [Reaction:R-HSA-5610735] NUMB binds ITCH - Homo sapiens [Reaction:R-HSA-1980125] ITCH binds DTX - Homo sapiens [Reaction:R-HSA-990526] Recruitment of ITCH and K48 ubiquitination of MAVS - Homo sapiens [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH - Homo sapiens [Reaction:R-HSA-9793451] MLKL binds ITCH - Homo sapiens
created	[InstanceEdit:976001] Garapati, P V, 2010-10-11
dbId	975995
displayName	ITCH [cytosol]
endCoordinate	903
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-975995] Itch [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-975995] Itch [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-975995] ITCH [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-975995] ITCH [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-975995] ITCH [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-975995] itchb [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-975995] itch [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-975995] ITCH [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-975995] Su(dx) [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-975995] wwp-1 [cytosol] - Caenorhabditis elegans [GenomeEncodedEntity:R-DDI-975995] Ghost homologue of ITCH [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-975995] pub3 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SPO-975995-2] pub1 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SPO-975995-3] pub2 [cytosol] - Schizosaccharomyces pombe [DefinedSet:R-SPO-975995-4] Homologues of ITCH [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-975995] RSP5 [cytosol] - Saccharomyces cerevisiae
maxDepth	1
memberOf	[CandidateSet:R-HSA-1248659] RIP2 ubiquitin ligases [cytosol] - Homo sapiens [DefinedSet:R-HSA-1253275] WWP1/ITCH [cytosol] - Homo sapiens
modified	[InstanceEdit:8983918] Jupe, Steve, 2017-03-31
name	ITCH E3 ubiquitin-protein ligase Itchy homolog ITCH_HUMAN AIP4
producedByEvent	[BlackBoxEvent:R-HSA-8956652] ITCH gene expression is stimulated by RUNX1 and YAP1 - Homo sapiens [BlackBoxEvent:R-HSA-9793444] ITCH polyubiquitinates MLKL at K50 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q96J02] UniProt:Q96J02 ITCH
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-975995
startCoordinate	1
updateTrackers	[UpdateTracker:9897057] Update Tracker - [EntityWithAccessionedSequence:975995] ITCH [cytosol] - v61:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9897057] Update Tracker - [EntityWithAccessionedSequence:975995] ITCH [cytosol] - v61:[addName]
(hasComponent)	[Complex:R-HSA-9685173] 9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane] [Complex:R-HSA-5610562] NUMB:ITCH [cytosol] [Complex:R-HSA-1911544] Ub-NOTCH1:NUMB:ITCH [plasma membrane] [Complex:R-HSA-1604458] NOTCH1:NUMB:ITCH [plasma membrane] [Complex:R-HSA-1911536] Ub-DTX:ITCH [cytosol] [Complex:R-HSA-1604453] DTX:ITCH [cytosol] [Complex:R-HSA-9793452] p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] [Complex:R-HSA-983459] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane]
(input)	[BlackBoxEvent:R-HSA-9685195] SARS-CoV-1 9b recruits ITCH to MAVS [Reaction:R-HSA-5610735] NUMB binds ITCH [Reaction:R-HSA-1980128] NOTCH1 associates with negative regulators NUMB and ITCH [Reaction:R-HSA-1980125] ITCH binds DTX [Reaction:R-HSA-9793451] MLKL binds ITCH [Reaction:R-HSA-990526] Recruitment of ITCH and K48 ubiquitination of MAVS
(output)	[BlackBoxEvent:R-HSA-8956652] ITCH gene expression is stimulated by RUNX1 and YAP1 [BlackBoxEvent:R-HSA-9793444] ITCH polyubiquitinates MLKL at K50
(activeUnit)	[CatalystActivity:5621778] ubiquitin protein ligase activity of NUMB:ITCH [cytosol] [CatalystActivity:5635830] ubiquitin protein ligase activity of GLI1:NUMB:ITCH [cytosol]
(hasMember)	[DefinedSet:R-HSA-1253275] WWP1/ITCH [cytosol] [CandidateSet:R-HSA-1248659] RIP2 ubiquitin ligases [cytosol]
(physicalEntity)	[CatalystActivity:990525] ubiquitin protein ligase activity of ITCH [cytosol]
(hasCandidate)	[CandidateSet:R-HSA-976075] E3 ligases in proteasomal degradation [cytosol]

Cite Us!