Reactome | Su(dx) [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-DME-976075] E3 ligases in proteasomal degradation [cytosol] - Drosophila melanogaster
catalystActivities	[CatalystActivity:10900507] ubiquitin protein ligase activity of ITCH [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-5610562] NUMB:ITCH [cytosol] - Drosophila melanogaster [Complex:R-DME-1911536] Ub-DTX:ITCH [cytosol] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-1980125] ITCH binds DTX - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10859340
displayName	Su(dx) [cytosol]
endCoordinate	903
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-975995] ITCH [cytosol] - Homo sapiens
maxDepth	1
name	Su(dx) ITCH Q9Y0H4
referenceEntity	[ReferenceGeneProduct:uniprot:Q9Y0H4] UniProt:Q9Y0H4
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-975995
startCoordinate	1

(physicalEntity)	[CatalystActivity:10900507] ubiquitin protein ligase activity of ITCH [cytosol]
(hasComponent)	[Complex:R-DME-5610562] NUMB:ITCH [cytosol] [Complex:R-DME-1911536] Ub-DTX:ITCH [cytosol] [Complex:R-DME-1604453] DTX:ITCH [cytosol]
(input)	[Reaction:R-DME-1980125] ITCH binds DTX
(hasCandidate)	[CandidateSet:R-DME-976075] E3 ligases in proteasomal degradation [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-975995] ITCH [cytosol]

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