Reactome | Itch [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-RNO-976075] E3 ligases in proteasomal degradation [cytosol] - Rattus norvegicus
catalystActivities	[CatalystActivity:10207192] ubiquitin protein ligase activity of ITCH [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-5610562] NUMB:ITCH [cytosol] - Rattus norvegicus [Complex:R-RNO-9793452] p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] - Rattus norvegicus [Complex:R-RNO-1911536] Ub-DTX:ITCH [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5610735] NUMB binds ITCH - Rattus norvegicus [Reaction:R-RNO-1980125] ITCH binds DTX - Rattus norvegicus [Reaction:R-RNO-9793451] MLKL binds ITCH - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10143800
displayName	Itch [cytosol]
endCoordinate	903
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-975995] ITCH [cytosol] - Homo sapiens
maxDepth	1
memberOf	[CandidateSet:R-RNO-1248659] RIP2 ubiquitin ligases [cytosol] - Rattus norvegicus [DefinedSet:R-RNO-1253275] WWP1/ITCH [cytosol] - Rattus norvegicus
name	Itch ITCH A0A0G2K9T1
producedByEvent	[BlackBoxEvent:R-RNO-9793444] ITCH polyubiquitinates MLKL at K50 - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:A0A0G2K9T1] UniProt:A0A0G2K9T1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-975995
startCoordinate	1

(physicalEntity)	[CatalystActivity:10207192] ubiquitin protein ligase activity of ITCH [cytosol]
(activeUnit)	[CatalystActivity:10178314] ubiquitin protein ligase activity of NUMB:ITCH [cytosol] [CatalystActivity:10180237] ubiquitin protein ligase activity of GLI1:NUMB:ITCH [cytosol]
(input)	[Reaction:R-RNO-5610735] NUMB binds ITCH [Reaction:R-RNO-1980125] ITCH binds DTX [Reaction:R-RNO-9793451] MLKL binds ITCH
(hasComponent)	[Complex:R-RNO-5610562] NUMB:ITCH [cytosol] [Complex:R-RNO-1911536] Ub-DTX:ITCH [cytosol] [Complex:R-RNO-1604453] DTX:ITCH [cytosol] [Complex:R-RNO-9793452] p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol]
(hasMember)	[DefinedSet:R-RNO-1253275] WWP1/ITCH [cytosol] [CandidateSet:R-RNO-1248659] RIP2 ubiquitin ligases [cytosol]
(output)	[BlackBoxEvent:R-RNO-9793444] ITCH polyubiquitinates MLKL at K50
(hasCandidate)	[CandidateSet:R-RNO-976075] E3 ligases in proteasomal degradation [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-975995] ITCH [cytosol]