Reactome | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730168
displayName	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
eventOf	[Pathway:R-XTR-975155] MyD88 dependent cascade initiated on endosome - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-933533] Dimerization of p-IRF7 - Xenopus tropicalis [Reaction:R-XTR-933531] Translocation of p-IRF7:p-IRF7 to nucleus - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-975110
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-975155] MyD88 dependent cascade initiated on endosome
(inferredTo)	[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Cite Us!