In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005).
TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling.
Taniguchi, T, Katsuki, M, Nakao, K, Sato, M, Hata, N, Ogasawara, K, Nakaya, T, Asagiri, M, Noguchi, S, Suemori, H, Tanaka, N
Taniguchi, T, Honda, K, Takaoka, A, Yanai, H
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