TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

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R-HSA-975110
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Pathway
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Homo sapiens
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In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005).

TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling.

Literature References
PubMed ID Title Journal Year
16214811 Regulation of the type I IFN induction: a current view

Honda, K, Yanai, H, Takaoka, A, Taniguchi, T

Int Immunol 2005
11070172 Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

Sato, M, Suemori, H, Hata, N, Asagiri, M, Ogasawara, K, Nakao, K, Nakaya, T, Katsuki, M, Noguchi, S, Tanaka, N, Taniguchi, T

Immunity 2000
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Orthologous Events
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BioModels Database
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