TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Stable Identifier
R-HSA-975110
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005).

TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling.

Literature References
PubMed ID Title Journal Year
11070172 Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

Taniguchi, T, Katsuki, M, Nakao, K, Sato, M, Hata, N, Ogasawara, K, Nakaya, T, Asagiri, M, Noguchi, S, Suemori, H, Tanaka, N

Immunity 2000
16214811 Regulation of the type I IFN induction: a current view

Taniguchi, T, Honda, K, Takaoka, A, Yanai, H

Int Immunol 2005
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