Reactome | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Stable Identifier

R-HSA-975110

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, endosome membrane

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TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

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In plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and IRAKs and translocates to the nucleus upon phosphorylation (Kawai et al 2004; Uematsu et al 2005).

TLR7/8 signaling was shown to induce IRF5 activation along with IRF7 [Schoenemeyer et al 2005], while IRF8 [Tsujimura H et al 2004] and IRF1 were reported to be implicated in TLR9 signaling.

Literature References

PubMed ID	Title	Journal	Year
16214811	Regulation of the type I IFN induction: a current view Honda, K, Yanai, H, Takaoka, A, Taniguchi, T	Int Immunol	2005
11070172	Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction Sato, M, Suemori, H, Hata, N, Asagiri, M, Ogasawara, K, Nakao, K, Nakaya, T, Katsuki, M, Noguchi, S, Tanaka, N, Taniguchi, T	Immunity	2000