Reactome | Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)

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Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:936971] Shamovsky, V, 2010-08-25
dbId	936964
displayName	Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
doi	10.3180/R-HSA-936964.6
edited	[InstanceEdit:1018388] Shamovsky, V, 2010-11-16
eventOf	[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1221070] TRIF-dependent toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2201338] TRAF3 binds TICAM1:activated TLR4 complex - Homo sapiens [BlackBoxEvent:R-HSA-2213017] Auto-ubiquitination of TRAF3 - Homo sapiens [Reaction:R-HSA-5362486] TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 - Homo sapiens [BlackBoxEvent:R-HSA-5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Homo sapiens [Reaction:R-HSA-9823932] Recruitment of IKK? (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Homo sapiens [Reaction:R-HSA-9824882] IKK? (IKBKE) is phosphorylated within the activated TLR4 complex - Homo sapiens [Reaction:R-HSA-9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 - Homo sapiens [Reaction:R-HSA-9823906] TBK1 is phosphorylated within the activated TLR4 complex - Homo sapiens [Reaction:R-HSA-166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 - Homo sapiens [Reaction:R-HSA-166245] Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex - Homo sapiens [Reaction:R-HSA-168933] Dimerization of phosphorylated IRF3/IRF7 - Homo sapiens [Reaction:R-HSA-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus - Homo sapiens [Pathway:R-HSA-9824878] Regulation of TBK1, IKK? (IKBKE)-mediated activation of IRF3, IRF7 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434099] IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts [LiteratureReference:434145] Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity [LiteratureReference:500589] Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling [LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE)
orthologousEvent	[Pathway:R-GGA-433835] IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3 - Gallus gallus [Pathway:R-GGA-434136] Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 - Gallus gallus [Pathway:R-GGA-433819] Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK - Gallus gallus [Pathway:R-GGA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Gallus gallus [Pathway:R-XTR-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Xenopus tropicalis [Pathway:R-SSC-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Sus scrofa [Pathway:R-BTA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Bos taurus [Pathway:R-CFA-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Canis familiaris [Pathway:R-RNO-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Rattus norvegicus [Pathway:R-MMU-936964] Activation of IRF3, IRF7 mediated by TBK1, IKK? (IKBKE) - Mus musculus
releaseDate	2010-12-14
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13 [InstanceEdit:5483106] Masci, Anna Maria, 2014-05-16 [InstanceEdit:9863305] Muniti?, Ivana, 2024-02-28 [InstanceEdit:9863304] Franjki?, Toni, 2024-02-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-936964
summation	[Summation:433991] Cell stimulation with viral double-stranded (ds) RNA and bac...

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[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling

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