Reactome | TRIF (TICAM1)-mediated TLR4 signaling

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TRIF (TICAM1)-mediated TLR4 signaling Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911244
displayName	TRIF (TICAM1)-mediated TLR4 signaling
eventOf	[Pathway:R-DME-166166] MyD88-independent TLR4 cascade - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221070] TRIF-dependent toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-DME-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Drosophila melanogaster [Pathway:R-DME-445989] TAK1-dependent IKK and NF-kappa-B activation - Drosophila melanogaster [Pathway:R-DME-450294] MAP kinase activation - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	TRIF (TICAM1)-mediated TLR4 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-937061
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-166166] MyD88-independent TLR4 cascade
(inferredTo)	[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling

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