Reactome | IKK complex recruitment mediated by RIP1

Schema > Pathway > Entries

IKK complex recruitment mediated by RIP1 Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
crossReference	[DatabaseIdentifier:12325418] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
dbId	937041
displayName	IKK complex recruitment mediated by RIP1
edited	[InstanceEdit:1014262] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Homo sapiens [Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens [Reaction:R-HSA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation [LiteratureReference:2423829] Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	IKK complex recruitment mediated by RIP1
orthologousEvent	[Pathway:R-GGA-434131] NFkB activation mediated by RIP1 complexed with activated TLR3 - Gallus gallus [Pathway:R-GGA-937041] IKK complex recruitment mediated by RIP1 - Gallus gallus [Pathway:R-SSC-937041] IKK complex recruitment mediated by RIP1 - Sus scrofa [Pathway:R-BTA-937041] IKK complex recruitment mediated by RIP1 - Bos taurus [Pathway:R-CFA-937041] IKK complex recruitment mediated by RIP1 - Canis familiaris [Pathway:R-RNO-937041] IKK complex recruitment mediated by RIP1 - Rattus norvegicus [Pathway:R-MMU-937041] IKK complex recruitment mediated by RIP1 - Mus musculus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-937041
summation	[Summation:433877] Receptor-interacting protein 1 (RIP1) mediates the activatio...

Referrals

(hasEvent)

[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling

Cite Us!