Reactome | TRAF6-mediated induction of TAK1 complex within TLR4 complex

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TRAF6-mediated induction of TAK1 complex within TLR4 complex Show undefined attributes

authored	[InstanceEdit:847735] Shamovsky, V, 2010-06-01
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:937065] Shamovsky, V, 2010-08-25
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	937072
displayName	TRAF6-mediated induction of TAK1 complex within TLR4 complex
edited	[InstanceEdit:1014302] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20248] canonical NF-kappaB signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-936985] Activated TLR4:TICAM1 recruits TRAF6 - Homo sapiens [BlackBoxEvent:R-HSA-936952] Auto ubiquitination of TRAF6 bound to the activated TLR4 complex - Homo sapiens [Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Homo sapiens [Reaction:R-HSA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex - Homo sapiens [Reaction:R-HSA-936951] Activation of TAK1 complex bound to activated TLR4 complex - Homo sapiens [Reaction:R-HSA-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-03-24
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:434114] TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	TRAF6-mediated induction of TAK1 complex within TLR4 complex
orthologousEvent	[Pathway:R-DDI-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Dictyostelium discoideum [Pathway:R-DME-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Drosophila melanogaster [Pathway:R-GGA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Gallus gallus [Pathway:R-DRE-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Danio rerio [Pathway:R-SSC-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Sus scrofa [Pathway:R-BTA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Bos taurus [Pathway:R-CFA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Canis familiaris [Pathway:R-RNO-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Rattus norvegicus [Pathway:R-MMU-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - Mus musculus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-937072
summation	[Summation:450322] In human, together with ubiquitin-conjugating E2-type enzyme...
updateTrackers	[UpdateTracker:9788418] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v42:[updateContainedRLE] [UpdateTracker:9789958] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v36:[updateContainedRLE] [UpdateTracker:9782309] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v59:[updateContainedRLE] [UpdateTracker:9776406] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v76:[updateContainedRLE] [UpdateTracker:9780632] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v62:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9788194] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v43:[updateContainedRLE] [UpdateTracker:9789117] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v38:[addLiteratureReference, modifyText] [UpdateTracker:9788546] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v41:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9788418] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v42:[updateContainedRLE]
[UpdateTracker:9789958] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v36:[updateContainedRLE]
[UpdateTracker:9782309] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v59:[updateContainedRLE]
[UpdateTracker:9776406] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v76:[updateContainedRLE]
[UpdateTracker:9780632] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v62:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9788194] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v43:[updateContainedRLE]
[UpdateTracker:9789117] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9788546] Update Tracker - [Pathway:937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex - v41:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling

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