Reactome | TRIF (TICAM1)-mediated TLR4 signaling

Schema > Pathway > Entries

created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11107108
displayName	TRIF (TICAM1)-mediated TLR4 signaling
eventOf	[Pathway:R-SCE-166166] MyD88-independent TLR4 cascade - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221070] TRIF-dependent toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-SCE-450294] MAP kinase activation - Saccharomyces cerevisiae
inferredFrom	[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	TRIF (TICAM1)-mediated TLR4 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-937061
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SCE-166166] MyD88-independent TLR4 cascade
(inferredTo)	[Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling

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