Reactome | MyD88-independent TLR4 cascade

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MyD88-independent TLR4 cascade Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:166165] de Bono, B, 2005-08-19 15:28:31
crossReference	[DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	166166
deleted	[Deleted:3558424] Deletion of instance: 1565008 [Deleted:9028194] Deletion of instance: 166054 [Deleted:3322332] Deletion of instance: 1485579
displayName	MyD88-independent TLR4 cascade
doi	10.3180/REACT_6809.8
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263660] MyD88-independent toll-like receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Homo sapiens [Reaction:R-HSA-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 - Homo sapiens [Pathway:R-HSA-937061] TRIF (TICAM1)-mediated TLR4 signaling - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:165842] MD-2: the Toll 'gatekeeper' in endotoxin signalling
maxDepth	7
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MyD88-independent TLR4 cascade
orthologousEvent	[Pathway:R-MMU-166166] MyD88-independent TLR4 cascade - Mus musculus [Pathway:R-RNO-166166] MyD88-independent TLR4 cascade - Rattus norvegicus [Pathway:R-BTA-166166] MyD88-independent TLR4 cascade - Bos taurus [Pathway:R-SSC-166166] MyD88-independent TLR4 cascade - Sus scrofa [Pathway:R-DRE-166166] MyD88-independent TLR4 cascade - Danio rerio [Pathway:R-XTR-166166] MyD88-independent TLR4 cascade - Xenopus tropicalis [Pathway:R-GGA-166166] MyD88-independent TLR4 cascade - Gallus gallus [Pathway:R-DME-166166] MyD88-independent TLR4 cascade - Drosophila melanogaster [Pathway:R-CFA-166166] MyD88-independent TLR4 cascade - Canis familiaris [Pathway:R-CEL-166166] MyD88-independent TLR4 cascade - Caenorhabditis elegans [Pathway:R-SPO-166166] MyD88-independent TLR4 cascade - Schizosaccharomyces pombe [Pathway:R-SCE-166166] MyD88-independent TLR4 cascade - Saccharomyces cerevisiae [Pathway:R-DDI-166166] MyD88-independent TLR4 cascade - Dictyostelium discoideum [Pathway:R-PFA-166166] MyD88-independent TLR4 cascade - Plasmodium falciparum
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
revised	[InstanceEdit:2558340] Shamovsky, V, 2012-11-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-166166
summation	[Summation:166412] The MyD88-independent signaling pathway is shared by TLR3 an...
updateTrackers	[UpdateTracker:9788319] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v43:[add_removeHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9846802] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v84:[updateContainedPathway] [UpdateTracker:9775258] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v80:[updateContainedPathway] [UpdateTracker:9842340] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v86:[modifyText, updateContainedPathway] [UpdateTracker:9788591] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v41:[add_removeHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9782769] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v58:[updateContainedRLE] [UpdateTracker:9789207] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v38:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784181] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v54:[updateContainedPathway] [UpdateTracker:9791870] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v25:[updateContainedRLE] [UpdateTracker:9780677] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v62:[removeHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9789741] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v37:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9784560] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v53:[updateContainedPathway] [UpdateTracker:9787513] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v45:[modifyText, updateContainedPathway, updateContainedRLE] [UpdateTracker:9864270] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v88:[updateContainedPathway] [UpdateTracker:9774716] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v81:[updateContainedPathway] [UpdateTracker:9785450] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v52:[updateContainedPathway] [UpdateTracker:9778581] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v68:[updateContainedPathway] [UpdateTracker:9786401] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v49:[updateContainedPathway]

Referrals

(hasEvent)	[Pathway:R-HSA-166016] Toll Like Receptor 4 (TLR4) Cascade
(hasEncapsulatedEvent)	[Pathway:R-HSA-5357769] Caspase activation via extrinsic apoptotic signalling pathway [Pathway:R-HSA-140534] Caspase activation via Death Receptors in the presence of ligand
(replacementInstances)	[Deleted:3558424] Deletion of instance: 1565008 [Deleted:9028194] Deletion of instance: 166054 [Deleted:3322332] Deletion of instance: 1485579
(updatedInstance)	[UpdateTracker:9788319] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v43:[add_removeHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9846802] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v84:[updateContainedPathway] [UpdateTracker:9775258] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v80:[updateContainedPathway] [UpdateTracker:9842340] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v86:[modifyText, updateContainedPathway] [UpdateTracker:9788591] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v41:[add_removeHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9782769] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v58:[updateContainedRLE] [UpdateTracker:9789207] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v38:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784181] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v54:[updateContainedPathway] [UpdateTracker:9791870] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v25:[updateContainedRLE] [UpdateTracker:9780677] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v62:[removeHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9789741] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v37:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9784560] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v53:[updateContainedPathway] [UpdateTracker:9787513] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v45:[modifyText, updateContainedPathway, updateContainedRLE] [UpdateTracker:9864270] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v88:[updateContainedPathway] [UpdateTracker:9774716] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v81:[updateContainedPathway] [UpdateTracker:9785450] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v52:[updateContainedPathway] [UpdateTracker:9778581] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v68:[updateContainedPathway] [UpdateTracker:9786401] Update Tracker - [Pathway:166166] MyD88-independent TLR4 cascade - v49:[updateContainedPathway]

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