Reactome | p-IRF7:p-IRF7 translocates to the nucleus

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p-IRF7:p-IRF7 translocates to the nucleus Show undefined attributes

authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
category	transition
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:9604488] Shamovsky, Veronica, 2018-04-03
dbId	9604487
displayName	p-IRF7:p-IRF7 translocates to the nucleus
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production - Homo sapiens
input	[Complex:R-HSA-450344] p-2S-IRF7:p-2S-IRF7 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:933500] Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain [LiteratureReference:933439] Structural insights into interferon regulatory factor activation [LiteratureReference:3134870] Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-IRF7:p-IRF7 translocates to the nucleus
negativePrecedingEvent	[NegativePrecedingEvent:9764721] Incorrect Order: DHX36 or DHX9 binds MyD88
orthologousEvent	[Reaction:R-MMU-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Mus musculus [Reaction:R-GGA-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Gallus gallus [Reaction:R-XTR-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Xenopus tropicalis [Reaction:R-DRE-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Danio rerio [Reaction:R-SSC-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Sus scrofa [Reaction:R-BTA-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Bos taurus [Reaction:R-RNO-9604487] p-IRF7:p-IRF7 translocates to the nucleus - Rattus norvegicus
output	[Complex:R-HSA-450306] 2xp-S477,S479-IRF7 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-933533] Dimerization of p-IRF7 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-3134857] Positive regulation by 'DHX36:CpG:MyD88 [cytosol]'
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9604487
summation	[Summation:9604489] p-IRF7 dimers are then transported into the nucleus and asse...

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[Pathway:R-HSA-3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production