Reactome | TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex

Schema > BlackBoxEvent > Entries

TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex Show undefined attributes

authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
catalystActivity	[CatalystActivity:1227771] ubiquitin-ubiquitin ligase activity of dsRNA:MDA5:IPS1:TRAF6/TRAF2 [mitochondrial outer membrane]
category	omitted
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:1227772] Shamovsky, V, 2011-03-10
dbId	1227769
displayName	TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
eventOf	[Pathway:R-GGA-1227892] TRAF6 mediated NF-kB activation - Gallus gallus
followingEvent	[Reaction:R-GGA-1227778] MEKK1 binds TRAF6 - Gallus gallus
inferredFrom	[Reaction:R-HSA-918230] Recruitment of TRAF6/TRAF2 to MAVS - Homo sapiens
input	[DefinedSet:R-GGA-1267865] dsRNA:MDA5:IPS1:TRAF6/or TRAF2 [mitochondrial outer membrane] 2 × [Polymer:R-GGA-434061] K63_polyubiquitin chain [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation [LiteratureReference:1250152] Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response [LiteratureReference:208040] Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex
output	[DefinedSet:R-GGA-1227773] dsRNA:MDA5:IPS1:K63-linked pUb TRAF6 or TRAF2 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-GGA-1227775] TRAF6/or TRAF2 interacts with IPS-1 - Gallus gallus
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
requiredInputComponent	[Complex:R-GGA-446245] Ubiquitin:UBE2N : UBE2V complex [cytosol] - Gallus gallus
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
schemaClass	BlackBoxEvent
species	[Species:49591] Gallus gallus
stId	R-GGA-1227769
summation	[Summation:1267868] TRAFs are E3 ubiquitin ligases that bind to an E2 - ubiquiti...

Referrals

(hasEvent)	[Pathway:R-GGA-1227892] TRAF6 mediated NF-kB activation
(precedingEvent)	[Reaction:R-GGA-1227778] MEKK1 binds TRAF6
(inferredTo)	[Reaction:R-HSA-918230] Recruitment of TRAF6/TRAF2 to MAVS

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