Reactome | Transferrin endocytosis and recycling

Schema > Pathway > Entries

Transferrin endocytosis and recycling Show undefined attributes

authored	[InstanceEdit:917902] Stephan, R, 2010-07-11
created	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
crossReference	[DatabaseIdentifier:12819689] BioModels Database:BIOMD0000000498
dbId	917977
displayName	Transferrin endocytosis and recycling
edited	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
eventOf	[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263816] transferrin transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5691154] HFE binds TFRC dimer - Homo sapiens [Reaction:R-HSA-917987] TFRC dimer binds 2xholoTF - Homo sapiens [Reaction:R-HSA-5691150] TFR2 dimer binds 2xholoTF - Homo sapiens [BlackBoxEvent:R-HSA-917807] holoTF:TFRC dimer translocates from plasma membrane to endosome membrane - Homo sapiens [Reaction:R-HSA-5252133] ATP6AP1 binds V-ATPase - Homo sapiens [Reaction:R-HSA-917841] Acidification of Tf:TfR1 containing endosome - Homo sapiens [Reaction:R-HSA-917835] Fe3+ dissociates from holoTF:TFRC dimer - Homo sapiens [Reaction:R-HSA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Homo sapiens [Reaction:R-HSA-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol - Homo sapiens [Reaction:R-HSA-917814] apoTF:TFRC dimer translocates from endosome membrane to plasma membrane - Homo sapiens [Reaction:R-HSA-917839] apo-Transferrin dissociates from the receptor complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[LiteratureReference:917921] Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Transferrin endocytosis and recycling
orthologousEvent	[Pathway:R-PFA-917977] Transferrin endocytosis and recycling - Plasmodium falciparum [Pathway:R-SCE-917977] Transferrin endocytosis and recycling - Saccharomyces cerevisiae [Pathway:R-SPO-917977] Transferrin endocytosis and recycling - Schizosaccharomyces pombe [Pathway:R-DDI-917977] Transferrin endocytosis and recycling - Dictyostelium discoideum [Pathway:R-CEL-917977] Transferrin endocytosis and recycling - Caenorhabditis elegans [Pathway:R-DME-917977] Transferrin endocytosis and recycling - Drosophila melanogaster [Pathway:R-GGA-917977] Transferrin endocytosis and recycling - Gallus gallus [Pathway:R-XTR-917977] Transferrin endocytosis and recycling - Xenopus tropicalis [Pathway:R-DRE-917977] Transferrin endocytosis and recycling - Danio rerio [Pathway:R-SSC-917977] Transferrin endocytosis and recycling - Sus scrofa [Pathway:R-BTA-917977] Transferrin endocytosis and recycling - Bos taurus [Pathway:R-CFA-917977] Transferrin endocytosis and recycling - Canis familiaris [Pathway:R-RNO-917977] Transferrin endocytosis and recycling - Rattus norvegicus [Pathway:R-MMU-917977] Transferrin endocytosis and recycling - Mus musculus
precedingEvent	[Reaction:R-HSA-917888] apoTF binds 2Fe3+ to form holoTF - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:994085] D'Eustachio, P, 2010-11-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-917977
summation	[Summation:917918] Endocytosis of iron loaded transferrin/receptor complex lead...
updateTrackers	[UpdateTracker:9785424] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v52:[addHasEvent] [UpdateTracker:9784635] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v53:[updateContainedRLE] [UpdateTracker:9789765] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v37:[updateContainedRLE] [UpdateTracker:9788701] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v41:[updateContainedRLE] [UpdateTracker:9864132] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v88:[updateContainedRLE] [UpdateTracker:9788746] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v40:[updateContainedRLE] [UpdateTracker:9781847] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v60:[addHasEvent]

Referrals

(updatedInstance)

[UpdateTracker:9785424] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v52:[addHasEvent]
[UpdateTracker:9784635] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v53:[updateContainedRLE]
[UpdateTracker:9789765] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v37:[updateContainedRLE]
[UpdateTracker:9788701] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v41:[updateContainedRLE]
[UpdateTracker:9864132] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v88:[updateContainedRLE]
[UpdateTracker:9788746] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v40:[updateContainedRLE]
[UpdateTracker:9781847] Update Tracker - [Pathway:917977] Transferrin endocytosis and recycling - v60:[addHasEvent]

(hasEvent)

[Pathway:R-HSA-917937] Iron uptake and transport

Cite Us!