Reactome | Transferrin endocytosis and recycling

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Transferrin endocytosis and recycling Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224023
displayName	Transferrin endocytosis and recycling
eventOf	[Pathway:R-RNO-917937] Iron uptake and transport - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:263816] transferrin transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-5691154] HFE binds TFRC dimer - Rattus norvegicus [Reaction:R-RNO-917987] TFRC dimer binds 2xholoTF - Rattus norvegicus [Reaction:R-RNO-5691150] TFR2 dimer binds 2xholoTF - Rattus norvegicus [BlackBoxEvent:R-RNO-917807] holoTF:TFRC dimer translocates from plasma membrane to endosome membrane - Rattus norvegicus [Reaction:R-RNO-5252133] ATP6AP1 binds V-ATPase - Rattus norvegicus [Reaction:R-RNO-917841] Acidification of Tf:TfR1 containing endosome - Rattus norvegicus [Reaction:R-RNO-917835] Fe3+ dissociates from holoTF:TFRC dimer - Rattus norvegicus [Reaction:R-RNO-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Rattus norvegicus [Reaction:R-RNO-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol - Rattus norvegicus [Reaction:R-RNO-917814] apoTF:TFRC dimer translocates from endosome membrane to plasma membrane - Rattus norvegicus [Reaction:R-RNO-917839] apo-Transferrin dissociates from the receptor complex - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Transferrin endocytosis and recycling
precedingEvent	[Reaction:R-RNO-917888] apoTF binds 2Fe3+ to form holoTF - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-917977
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-917937] Iron uptake and transport
(inferredTo)	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling