Reactome | apoTF binds 2Fe3+ to form holoTF

Schema > Reaction > Entries

apoTF binds 2Fe3+ to form holoTF Show undefined attributes

authored	[InstanceEdit:917867] Stephan, R, 2010-07-07
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
dbId	917888
displayName	apoTF binds 2Fe3+ to form holoTF
edited	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
eventOf	[Pathway:R-HSA-917937] Iron uptake and transport - Homo sapiens
followingEvent	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling - Homo sapiens [Reaction:R-HSA-917987] TFRC dimer binds 2xholoTF - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-350754] apoTF [extracellular region] 2 × [SimpleEntity:R-ALL-912516] Fe3+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:917790] The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	apoTF binds 2Fe3+ to form holoTF apo-Transferrin is loaded with two iron ions
orthologousEvent	[Reaction:R-MMU-917888] apoTF binds 2Fe3+ to form holoTF - Mus musculus [Reaction:R-DME-917888] apoTF binds 2Fe3+ to form holoTF - Drosophila melanogaster [Reaction:R-GGA-917888] apoTF binds 2Fe3+ to form holoTF - Gallus gallus [Reaction:R-DRE-917888] apoTF binds 2Fe3+ to form holoTF - Danio rerio [Reaction:R-SSC-917888] apoTF binds 2Fe3+ to form holoTF - Sus scrofa [Reaction:R-BTA-917888] apoTF binds 2Fe3+ to form holoTF - Bos taurus [Reaction:R-RNO-917888] apoTF binds 2Fe3+ to form holoTF - Rattus norvegicus
output	[Complex:R-HSA-917889] holoTF [extracellular region]
precedingEvent	[Reaction:R-HSA-917891] SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ - Homo sapiens [Reaction:R-HSA-917933] SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:994085] D'Eustachio, P, 2010-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-917888
summation	[Summation:917864] Transferrin (TF) is the main transporter of iron in the bloo...
updateTrackers	[UpdateTracker:9784837] Update Tracker - [Reaction:917888] apoTF binds 2Fe3+ to form holoTF - v53:[modifyText] [UpdateTracker:9780453] Update Tracker - [Reaction:917888] apoTF binds 2Fe3+ to form holoTF - v63:[add_removeInput]

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(updatedInstance)	[UpdateTracker:9784837] Update Tracker - [Reaction:917888] apoTF binds 2Fe3+ to form holoTF - v53:[modifyText] [UpdateTracker:9780453] Update Tracker - [Reaction:917888] apoTF binds 2Fe3+ to form holoTF - v63:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-917937] Iron uptake and transport
(precedingEvent)	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling [Reaction:R-HSA-917987] TFRC dimer binds 2xholoTF