Reactome | STEAP3,STEAP4 reduce Fe3+ to Fe2+

Schema > Reaction > Entries

STEAP3,STEAP4 reduce Fe3+ to Fe2+ Show undefined attributes

authored	[InstanceEdit:917986] Stephan, R, 2010-07-14
catalystActivity	[CatalystActivity:917825] ferric-chelate reductase (NADPH) activity of STEAP3,STEAP4 [endosome membrane]
category	transition
compartment	[Compartment:171907] endosome lumen [Compartment:74700] endosome membrane
created	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
crossReference	[DatabaseIdentifier:9861424] RHEA:71769
dbId	917811
displayName	STEAP3,STEAP4 reduce Fe3+ to Fe2+
edited	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
eventOf	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling - Homo sapiens
followingEvent	[Reaction:R-HSA-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-111736] Fe3+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:917953] Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells [LiteratureReference:917932] The Steap proteins are metalloreductases [LiteratureReference:9861422] Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins [LiteratureReference:9861423] Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	STEAP3,STEAP4 reduce Fe3+ to Fe2+ 2 Fe(3+) + NADPH => 2 Fe(2+) + H(+) + NADP(+) Reduction of Fe3+ in the endosome
orthologousEvent	[Reaction:R-GGA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Gallus gallus [Reaction:R-XTR-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Xenopus tropicalis [Reaction:R-DRE-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Danio rerio [Reaction:R-SSC-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Sus scrofa [Reaction:R-BTA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Bos taurus [Reaction:R-CFA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Canis familiaris [Reaction:R-RNO-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Rattus norvegicus [Reaction:R-MMU-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Mus musculus
output	[SimpleEntity:R-ALL-917810] Fe2+ [endosome lumen] [SimpleEntity:R-ALL-74722] H+ [endosome lumen] [SimpleEntity:R-ALL-9861421] NADP+ [endosome lumen]
precedingEvent	[Reaction:R-HSA-917835] Fe3+ dissociates from holoTF:TFRC dimer - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:994085] D'Eustachio, P, 2010-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-917811
summation	[Summation:917796] The iron ions that are no longer bound to transferrin are re...
updateTrackers	[UpdateTracker:9864286] Update Tracker - [Reaction:917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - v88:[addLiteratureReference, addOutput, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864286] Update Tracker - [Reaction:917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - v88:[addLiteratureReference, addOutput, add_removeInput, modifyText]
(precedingEvent)	[Reaction:R-HSA-917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol
(hasEvent)	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling