Reactome | Fe3+ dissociates from holoTF:TFRC dimer

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Fe3+ dissociates from holoTF:TFRC dimer Show undefined attributes

authored	[InstanceEdit:917986] Stephan, R, 2010-07-14
category	dissociation
compartment	[Compartment:171907] endosome lumen [Compartment:74700] endosome membrane
created	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
dbId	917835
displayName	Fe3+ dissociates from holoTF:TFRC dimer
edited	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
eventOf	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling - Homo sapiens
followingEvent	[Reaction:R-HSA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - Homo sapiens [Reaction:R-HSA-917814] apoTF:TFRC dimer translocates from endosome membrane to plasma membrane - Homo sapiens
input	[Complex:R-HSA-917799] holoTF:TFRC dimer [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:917875] The mechanism of iron release from the transferrin-receptor 1 adduct
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Fe3+ dissociates from holoTF:TFRC dimer
orthologousEvent	[Reaction:R-GGA-917835] Fe3+ dissociates from holoTF:TFRC dimer - Gallus gallus [Reaction:R-DRE-917835] Fe3+ dissociates from holoTF:TFRC dimer - Danio rerio [Reaction:R-SSC-917835] Fe3+ dissociates from holoTF:TFRC dimer - Sus scrofa [Reaction:R-BTA-917835] Fe3+ dissociates from holoTF:TFRC dimer - Bos taurus [Reaction:R-RNO-917835] Fe3+ dissociates from holoTF:TFRC dimer - Rattus norvegicus [Reaction:R-MMU-917835] Fe3+ dissociates from holoTF:TFRC dimer - Mus musculus
output	[Complex:R-HSA-917912] apoTF:TFRC dimer [endosome membrane] 4 × [SimpleEntity:R-ALL-917966] Fe3+ [endosome lumen]
precedingEvent	[Reaction:R-HSA-917841] Acidification of Tf:TfR1 containing endosome - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:994085] D'Eustachio, P, 2010-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-917835
summation	[Summation:917967] When endosomal pH reaches 6,0, protons replace the iron ions...

Referrals

(precedingEvent)	[Reaction:R-HSA-917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ [Reaction:R-HSA-917814] apoTF:TFRC dimer translocates from endosome membrane to plasma membrane
(hasEvent)	[Pathway:R-HSA-917977] Transferrin endocytosis and recycling

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