Reactome | Regulation of expression of SLITs and ROBOs

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Regulation of expression of SLITs and ROBOs Show undefined attributes

authored	[InstanceEdit:9010552] Orlic-Milacic, Marija, 2017-06-27
created	[InstanceEdit:9010552] Orlic-Milacic, Marija, 2017-06-27
dbId	9010553
displayName	Regulation of expression of SLITs and ROBOs
edited	[InstanceEdit:9014884] Orlic-Milacic, Marija, 2017-08-04
eventOf	[Pathway:R-HSA-376176] Signaling by ROBO receptors - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9010541] ISL1 binds the SLIT2 gene enhancer - Homo sapiens [BlackBoxEvent:R-HSA-9010539] SLIT2 gene expression is stimulated by ISL1 - Homo sapiens [Reaction:R-HSA-9010872] SLIT2 binds Dystroglycan - Homo sapiens [Reaction:R-HSA-9010396] SLIT1 binds COL4A5 - Homo sapiens [Reaction:R-HSA-9011074] LHX2 binds to ROBO1 gene locus - Homo sapiens [BlackBoxEvent:R-HSA-9011083] ROBO1 gene expression is inhibited by LHX2 - Homo sapiens [Reaction:R-HSA-8986083] USP33 deubiquitinates ROBO1 - Homo sapiens [Reaction:R-HSA-9010503] HOXA2 binds ROBO2 gene promoter - Homo sapiens [Reaction:R-HSA-9011077] LHX2 binds to ROBO2 gene locus - Homo sapiens [BlackBoxEvent:R-HSA-9010523] ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 - Homo sapiens [Reaction:R-HSA-9011145] LHX2,(LHX9) binds the ROBO3 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-9011143] ROBO3.1 expression is stimulated by LHX2,(LHX9) - Homo sapiens [Reaction:R-HSA-9011346] MSI1 binds ROBO3.1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9011347] ROBO3.1 mRNA translation is positively regulated by MSI1 - Homo sapiens [BlackBoxEvent:R-HSA-9011289] ZSWIM8 binds ROBO3.1 - Homo sapiens [BlackBoxEvent:R-HSA-9011300] ZSWIM8 ubiquitinates ROBO3.1 - Homo sapiens [BlackBoxEvent:R-HSA-9011313] Proteasome degrades ubiquitinated ROBO3.1 - Homo sapiens [BlackBoxEvent:R-HSA-9014587] Transcription of ROBO3.2 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9014610] Translation of ROBO3.2 mRNA initiates NMD - Homo sapiens [BlackBoxEvent:R-HSA-9014652] Translation of ROBO3.2 mRNA is negatively regulated by NMD - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9011138] A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors [LiteratureReference:9011085] The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors [LiteratureReference:9010542] ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons [LiteratureReference:9010501] Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling [LiteratureReference:9011341] Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression [LiteratureReference:9011279] The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons [LiteratureReference:8986103] Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration [LiteratureReference:8986096] USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration [LiteratureReference:9011429] Dystroglycan organizes axon guidance cue localization and axonal pathfinding [LiteratureReference:9010444] Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling [LiteratureReference:9010474] Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord [LiteratureReference:9010401] Assembly of lamina-specific neuronal connections by slit bound to type IV collagen
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Regulation of expression of SLITs and ROBOs
orthologousEvent	[Pathway:R-CEL-9010553] Regulation of expression of SLITs and ROBOs - Caenorhabditis elegans [Pathway:R-DME-9010553] Regulation of expression of SLITs and ROBOs - Drosophila melanogaster [Pathway:R-GGA-9010553] Regulation of expression of SLITs and ROBOs - Gallus gallus [Pathway:R-SSC-9010553] Regulation of expression of SLITs and ROBOs - Sus scrofa [Pathway:R-BTA-9010553] Regulation of expression of SLITs and ROBOs - Bos taurus [Pathway:R-CFA-9010553] Regulation of expression of SLITs and ROBOs - Canis familiaris [Pathway:R-MMU-9010553] Regulation of expression of SLITs and ROBOs - Mus musculus
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9010553
summation	[Summation:9011433] Expression of SLIT and ROBO proteins is regulated at the lev...

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[Pathway:R-HSA-376176] Signaling by ROBO receptors

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