Reactome | Translation of ROBO3.2 mRNA is negatively regulated by NMD

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Translation of ROBO3.2 mRNA is negatively regulated by NMD Show undefined attributes

authored	[InstanceEdit:9009836] Orlic-Milacic, Marija, 2017-06-23
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9014654] Orlic-Milacic, Marija, 2017-08-02
dbId	9014652
displayName	Translation of ROBO3.2 mRNA is negatively regulated by NMD
edited	[InstanceEdit:9014888] Orlic-Milacic, Marija, 2017-08-04
eventOf	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs - Homo sapiens
followingEvent	[Reaction:R-HSA-9010190] ROBO3 binds NELL2 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9014678] Translation of Robo3.2 mRNA is negatively regulated by NMD - Mus musculus
input	[GenomeEncodedEntity:R-HSA-9014585] ROBO3.2 mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9014608] Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translation of ROBO3.2 mRNA is negatively regulated by NMD
output	[GenomeEncodedEntity:R-HSA-9014651] ROBO3.2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9014587] Transcription of ROBO3.2 mRNA - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-9014653] Negative gene expression regulation by 'Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol]'
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9014652
summation	[Summation:9014680] Based on studies in mice, translation of ROBO3.2 mRNA in com...

Referrals

(precedingEvent)	[Reaction:R-HSA-9010190] ROBO3 binds NELL2
(hasEvent)	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs
(inferredTo)	[BlackBoxEvent:R-MMU-9014678] Translation of Robo3.2 mRNA is negatively regulated by NMD

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