Reactome | ISL1 binds the SLIT2 gene enhancer

Schema > Reaction > Entries

authored	[InstanceEdit:9009836] Orlic-Milacic, Marija, 2017-06-23
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9010552] Orlic-Milacic, Marija, 2017-06-27
dbId	9010541
displayName	ISL1 binds the SLIT2 gene enhancer
edited	[InstanceEdit:9014888] Orlic-Milacic, Marija, 2017-08-04
eventOf	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9010539] SLIT2 gene expression is stimulated by ISL1 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9010548] Isl1 binds the Slit2 gene enhancer - Mus musculus
input	[DefinedSet:R-HSA-9010608] ISL1:LHX3/4:LDB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9010561] SLIT2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ISL1 binds the SLIT2 gene enhancer
output	[Complex:R-HSA-9010606] ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9010541
summation	[Summation:9010629] Based on studies in mice, the transcription factor ISL1, in ...

(hasEvent)	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs
(precedingEvent)	[BlackBoxEvent:R-HSA-9010539] SLIT2 gene expression is stimulated by ISL1
(inferredTo)	[Reaction:R-MMU-9010548] Isl1 binds the Slit2 gene enhancer

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