Reactome | ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2

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ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2 Show undefined attributes

authored	[InstanceEdit:9009836] Orlic-Milacic, Marija, 2017-06-23
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9010526] Orlic-Milacic, Marija, 2017-06-27
dbId	9010523
displayName	ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2
edited	[InstanceEdit:9014888] Orlic-Milacic, Marija, 2017-08-04
eventOf	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs - Homo sapiens
followingEvent	[Reaction:R-HSA-9010648] ROBO2 binds AKAP5 - Homo sapiens [Reaction:R-HSA-9010898] ROBO2 binds SLIT2 - Homo sapiens [BlackBoxEvent:R-HSA-428510] ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing - Homo sapiens [Reaction:R-HSA-9014834] ROBO1,ROBO2 bind SLIT3 - Homo sapiens [Reaction:R-HSA-8985799] SLIT1 binds ROBO1,(ROBO2) - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9010527] Robo2 gene expression is stimulated by Hoxa2 and inhibited by Lhx2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9010496] ROBO2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ROBO2 gene transcription is stimulated by HOXA2 and inhibited by LHX2
output	[EntityWithAccessionedSequence:R-HSA-197747] ROBO2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9010503] HOXA2 binds ROBO2 gene promoter - Homo sapiens [Reaction:R-HSA-9011077] LHX2 binds to ROBO2 gene locus - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-9010524] Positive gene expression regulation by 'HOXA2:ROBO2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-9011104] Negative gene expression regulation by 'LHX2:ROBO2 gene [nucleoplasm]'
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9010523
summation	[Summation:9010522] Based on studies in mice, the homeobox transcription factor ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9010648] ROBO2 binds AKAP5 [BlackBoxEvent:R-HSA-428510] ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing [Reaction:R-HSA-9014834] ROBO1,ROBO2 bind SLIT3 [Reaction:R-HSA-8985799] SLIT1 binds ROBO1,(ROBO2) [Reaction:R-HSA-9010898] ROBO2 binds SLIT2
(hasEvent)	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs
(inferredTo)	[BlackBoxEvent:R-MMU-9010527] Robo2 gene expression is stimulated by Hoxa2 and inhibited by Lhx2