Reactome | SLIT2 gene expression is stimulated by ISL1

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SLIT2 gene expression is stimulated by ISL1 Show undefined attributes

authored	[InstanceEdit:9009836] Orlic-Milacic, Marija, 2017-06-23
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9010552] Orlic-Milacic, Marija, 2017-06-27
dbId	9010539
displayName	SLIT2 gene expression is stimulated by ISL1
edited	[InstanceEdit:9014888] Orlic-Milacic, Marija, 2017-08-04
eventOf	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs - Homo sapiens
followingEvent	[Reaction:R-HSA-9010815] SLITs bind keratan sulfate - Homo sapiens [Reaction:R-HSA-9010872] SLIT2 binds Dystroglycan - Homo sapiens [Reaction:R-HSA-204364] ROBO1 binds SLIT2 - Homo sapiens [Reaction:R-HSA-376149] Proteolytic processing of SLIT - Homo sapiens [Reaction:R-HSA-428518] Glypican-1 (GPC1) binds SLIT2 - Homo sapiens [Reaction:R-HSA-9010898] ROBO2 binds SLIT2 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9010544] Slit2 gene expression is stimulated by Isl1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9010561] SLIT2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SLIT2 gene expression is stimulated by ISL1
output	[EntityWithAccessionedSequence:R-HSA-375997] SLIT2 [extracellular region]
precedingEvent	[Reaction:R-HSA-9010541] ISL1 binds the SLIT2 gene enhancer - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-9010614] Positive gene expression regulation by 'ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm]'
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9010539
summation	[Summation:9010632] Based on studies in mice, the transcription factor ISL1, in ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9010815] SLITs bind keratan sulfate [Reaction:R-HSA-9010872] SLIT2 binds Dystroglycan [Reaction:R-HSA-204364] ROBO1 binds SLIT2 [Reaction:R-HSA-428518] Glypican-1 (GPC1) binds SLIT2 [Reaction:R-HSA-376149] Proteolytic processing of SLIT [Reaction:R-HSA-9010898] ROBO2 binds SLIT2
(hasEvent)	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs
(inferredTo)	[BlackBoxEvent:R-MMU-9010544] Slit2 gene expression is stimulated by Isl1