Reactome | USP33 deubiquitinates ROBO1

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USP33 deubiquitinates ROBO1 Show undefined attributes

authored	[InstanceEdit:9009836] Orlic-Milacic, Marija, 2017-06-23
catalystActivity	[CatalystActivity:8986097] cysteine-type deubiquitinase activity of USP33 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8986087] Orlic-Milacic, Marija, 2017-04-21
dbId	8986083
displayName	USP33 deubiquitinates ROBO1
edited	[InstanceEdit:9014888] Orlic-Milacic, Marija, 2017-08-04
eventOf	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-HSA-8986095] PolyUb-ROBO1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8986096] USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration [LiteratureReference:8986103] Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	USP33 deubiquitinates ROBO1
orthologousEvent	[Reaction:R-DME-8986083] USP33 deubiquitinates ROBO1 - Drosophila melanogaster [Reaction:R-BTA-8986083] USP33 deubiquitinates ROBO1 - Bos taurus [Reaction:R-MMU-8986083] USP33 deubiquitinates ROBO1 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-204361] ROBO1 [plasma membrane] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8986083
summation	[Summation:8986081] The ubiquitin protease USP33 deubiquitinates ROBO1, thus sta...

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(hasEvent)

[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs