Reactome | Signaling by ROBO receptors

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Signaling by ROBO receptors Show undefined attributes

authored	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05
dbId	376176
displayName	Signaling by ROBO receptors
doi	10.3180/R-HSA-376176.3
edited	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05 [InstanceEdit:9009839] Orlic-Milacic, Marija, 2017-06-23 [InstanceEdit:9014884] Orlic-Milacic, Marija, 2017-08-04
eventOf	[Pathway:R-HSA-422475] Axon guidance - Homo sapiens
figure	[Figure:9677021] /figures/static/R-HSA-376176.svg
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9010553] Regulation of expression of SLITs and ROBOs - Homo sapiens [Reaction:R-HSA-376149] Proteolytic processing of SLIT - Homo sapiens [Reaction:R-HSA-428518] Glypican-1 (GPC1) binds SLIT2 - Homo sapiens [Reaction:R-HSA-9010815] SLITs bind keratan sulfate - Homo sapiens [Reaction:R-HSA-9014812] ROBOs bind keratan sulfate - Homo sapiens [Reaction:R-HSA-204364] ROBO1 binds SLIT2 - Homo sapiens [Reaction:R-HSA-9010898] ROBO2 binds SLIT2 - Homo sapiens [Reaction:R-HSA-9014834] ROBO1,ROBO2 bind SLIT3 - Homo sapiens [Pathway:R-HSA-428542] Regulation of commissural axon pathfinding by SLIT and ROBO - Homo sapiens [Pathway:R-HSA-8985801] Regulation of cortical dendrite branching - Homo sapiens [Reaction:R-HSA-376140] Ena/VASP proteins bind ROBO1:SLIT2 complex - Homo sapiens [Reaction:R-HSA-428534] Recruitment of Profilin by Ena/VASP proteins - Homo sapiens [Pathway:R-HSA-428543] Inactivation of CDC42 and RAC1 - Homo sapiens [Pathway:R-HSA-428540] Activation of RAC1 - Homo sapiens [Pathway:R-HSA-428890] Role of ABL in ROBO-SLIT signaling - Homo sapiens [Pathway:R-HSA-8985586] SLIT2:ROBO1 increases RHOA activity - Homo sapiens [Reaction:R-HSA-8986258] SLIT2:ROBO1 binds CXCR4 - Homo sapiens [Reaction:R-HSA-9010231] ROBO1 binds FLRT3 - Homo sapiens [Pathway:R-HSA-9010642] ROBO receptors bind AKAP5 - Homo sapiens [Reaction:R-HSA-9010951] ROBO1 binds NRP1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-03-16
literatureReference	[LiteratureReference:375905] Structural insight into Slit-Robo signalling [LiteratureReference:9010261] Slit/Robo signaling modulates the proliferation of central nervous system progenitors [LiteratureReference:9010278] Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth [LiteratureReference:9010382] Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling [LiteratureReference:9010877] Repulsive axon guidance molecule Slit3 is a novel angiogenic factor [LiteratureReference:9011371] Slit-Robo signaling [LiteratureReference:9011372] Roundabout receptors [LiteratureReference:9010189] Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2
maxDepth	3
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Signaling by ROBO receptors
orthologousEvent	[Pathway:R-MMU-376176] Signaling by ROBO receptors - Mus musculus [Pathway:R-RNO-376176] Signaling by ROBO receptors - Rattus norvegicus [Pathway:R-CFA-376176] Signaling by ROBO receptors - Canis familiaris [Pathway:R-BTA-376176] Signaling by ROBO receptors - Bos taurus [Pathway:R-SSC-376176] Signaling by ROBO receptors - Sus scrofa [Pathway:R-DRE-376176] Signaling by ROBO receptors - Danio rerio [Pathway:R-XTR-376176] Signaling by ROBO receptors - Xenopus tropicalis [Pathway:R-GGA-376176] Signaling by ROBO receptors - Gallus gallus [Pathway:R-DME-376176] Signaling by ROBO receptors - Drosophila melanogaster [Pathway:R-CEL-376176] Signaling by ROBO receptors - Caenorhabditis elegans
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:434966] Kidd, T, 2009-08-18 [InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
revised	[InstanceEdit:9009836] Orlic-Milacic, Marija, 2017-06-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-376176
summation	[Summation:375908] The Roundabout (ROBO) family encodes transmembrane receptors...
updateTrackers	[UpdateTracker:9780913] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v61:[updateIndirectRLE] [UpdateTracker:9789252] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v38:[updateContainedPathway] [UpdateTracker:9779209] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v66:[updateContainedRLE] [UpdateTracker:9864349] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v88:[updateIndirectRLE] [UpdateTracker:9780551] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v62:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9777138] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v72:[updateContainedRLE] [UpdateTracker:9791071] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v32:[updateIndirectRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-422475] Axon guidance

(updatedInstance)

[UpdateTracker:9780913] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v61:[updateIndirectRLE]
[UpdateTracker:9789252] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v38:[updateContainedPathway]
[UpdateTracker:9779209] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v66:[updateContainedRLE]
[UpdateTracker:9864349] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v88:[updateIndirectRLE]
[UpdateTracker:9780551] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v62:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9777138] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v72:[updateContainedRLE]
[UpdateTracker:9791071] Update Tracker - [Pathway:376176] Signaling by ROBO receptors - v32:[updateIndirectRLE]

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